Document Detail

Differences in airway wall compliance as a possible mechanism for wheezing disorders in infants.
MedLine Citation:
PMID:  9701428     Owner:  NLM     Status:  MEDLINE    
High-frequency input impedance measurements (Z(f)) provide useful noninvasive information on airway geometry and especially airway wall mechanics in the canine and human adult respiratory system. Using the high-speed interrupter technique (HIT), we have shown that it is possible to measure high-frequency Z(f) in infants up to 900 Hz, including antiresonant phenomena which are known to be related to wave propagation velocity. This implies that the first antiresonant frequency (far,1) is a function of airway wall compliance. Since, airway wall mechanics are particularly important for the flow limitation phenomena, we wondered whether we could find evidence that airway wall properties were important for the occurrence of flow limitation during incremental methacholine challenge in infants. We measured Z(f) from 32-900 Hz and maximal flow at functional residual capacity (V'maxFRC) by the rapid chest compression technique in 10 infants (aged 36-81 weeks) with wheezing disorders. far,1 increased significantly at very low doses of mch before any decline could be detected in V'maxFRC. We hypothesize that these changes in far,1 are determined by mch-induced decrease in airway wall compliance. High-speed interrupter technique in combination with rapid chest compression technique can be used to study developmental differences in airway function (particularly of airway wall properties) and their contribution to airway disease and response to bronchodilator therapy in infants.
U Frey; A C Jackson; M Silverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  12     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  136-42     Citation Subset:  IM    
Dept of Child Health, University of Leicester School of Medicine, UK.
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MeSH Terms
Airway Resistance / physiology*
Bronchial Provocation Tests
Functional Residual Capacity / physiology
Methacholine Chloride / diagnostic use
Muscle, Smooth / physiopathology
Pulmonary Ventilation / physiology
Respiratory Sounds / etiology,  physiopathology*
Reg. No./Substance:
62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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