Document Detail

Differences in airway responsiveness to acetaldehyde and methacholine in asthma and chronic bronchitis.
MedLine Citation:
PMID:  10706489     Owner:  NLM     Status:  MEDLINE    
Inhaled acetaldehyde may induce bronchoconstriction in asthmatic subjects and provides a new method to investigate airway responsiveness. The objective of the study was to determine whether acetaldehyde was a more specific stimulus than methacholine in differentiating asthma from chronic bronchitis with or without airflow limitation. Bronchial provocation challenges with methacholine and acetaldehyde were performed in 62 asthmatics and in 59 smokers with chronic bronchitis (32 with chronic bronchitis alone and 27 with chronic bronchitis and coexisting chronic obstructive pulmonary disease (COPD)). The response to both bronchoconstrictor agents was measured by the provocative concentration required to produce a 20% fall in forced expiratory volume in one second (FEV1; PC20). The two types of challenge yielded a similarly high level of sensitivity (100% for methacholine and 92% for acetaldehyde) in revealing airway hyperresponsiveness in asthma. However, bronchoprovocation with acetaldehyde yielded considerably greater specificity (95%) than bronchoprovocation with methacholine (24%) in separating asthma from chronic bronchitis. In subjects with asthma, methacholine and acetaldehyde responsiveness were weakly but significantly correlated (r=0.42, p=0.001) but no correlation was found between airway responsiveness to acetaldehyde and baseline FEV1 (r=0.13, p=0.33). These findings suggest that the demonstration of bronchoconstriction in response to acetaldehyde may be a more specific test than methacholine in the differentiation of asthma from chronic bronchitis. Furthermore, methacholine and acetaldehyde hyperresponsiveness are not reflecting the same pathophysiological process in the airways.
F Sánchez-Toril; L Prieto; R Peris; J A Pérez; M Millan; J Marín
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  15     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-28     Completed Date:  2000-03-28     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  260-5     Citation Subset:  IM    
Servicio de Neumologá, Hospital Arnau de Vilanova, Valencia, Spain.
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MeSH Terms
Acetaldehyde / diagnostic use*
Asthma / diagnosis,  physiopathology*
Bronchial Hyperreactivity / physiopathology*
Bronchial Provocation Tests
Bronchitis / diagnosis,  physiopathology*
Bronchoconstrictor Agents / diagnostic use*
Diagnosis, Differential
Lung Diseases, Obstructive / physiopathology
Methacholine Chloride / diagnostic use*
Middle Aged
Sensitivity and Specificity
Smoking / physiopathology
Reg. No./Substance:
0/Bronchoconstrictor Agents; 62-51-1/Methacholine Chloride; 75-07-0/Acetaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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