Document Detail

Differences in acute metabolism of fructose between hemodialysis patients and healthy subjects.
MedLine Citation:
PMID:  23336588     Owner:  NLM     Status:  Publisher    
The consumption of fructose has increased dramatically during the last few decades and parallels the epidemics of obesity, metabolic syndrome, diabetes and chronic kidney disease (CKD). Fructose occurs naturally e.g. in fruit and in honey (rich in this monosaccharide) and as sucrose (table sugar). The effects of fructose have been attributed to the transient increases in serum uric acid levels during its metabolism. Recent research, also in CKD patients, has linked fructose to dysmetabolism of lipids, glucose and oxidative radicals. However, a general consensus of the potentially harmful effects of fructose is lacking. We improved a sensitive inulin assay for fructose measurement in serum and plasma and tested its accuracy in an acute experiment following consumption of pure fructose in controls. In addition, fructose and uric acid were analyzed postprandially during 240 min in six maintenance hemodialysis (HD) patients and nine healthy subjects consuming 190 ml cream/75 g sucrose in a fasting state. Whereas the fructose levels reached a maximum level after 60 min in controls they had not even started to decrease at 240 min in HD-patients. Likewise, while uric acid levels remained stable in controls they increased by 10% in HD patients at 240 min following the meal. In conclusion, a glucose and fat rich meal is associated with delayed absorption and/or metabolism of fructose in HD patients as well as increased serum uric acid levels.
Björn Anderstam; Ann-Christin Bragfors-Helin; Jonas Axelsson; Abdul R Qureshi; Rolf Wibom; Bengt Lindholm; Peter Stenvinkel
Related Documents :
23390188 - Gender difference of serum angiotensin-converting enzyme (ace) activity in dd genotype ...
24903198 - Prolactin is associated with metabolic risk and cortisol in 1007 women with polycystic ...
24203058 - Plasma apolipoprotein b-48 transport in obese men: a new tracer kinetic study in the po...
23732398 - Plasma homocysteine and folate levels and dietary folate intake in adolescents and youn...
1624088 - Somatolactin stimulates in vitro gonadal steroidogenesis in coho salmon, oncorhynchus k...
9469268 - Maternal serum interleukin-6 concentration as a marker for impending preterm delivery.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-22
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  -     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The effect of BLyS on the activity of peripheral B lymphocytes mediated by BLyS receptors in patient...
Next Document:  Inflammatory bowel disease: perspectives from cingulate cortex in the first brain.