Document Detail

Differences in the acute and chronic antihypertensive effects of lisinopril and enalapril assessed by ambulatory blood pressure monitoring.
MedLine Citation:
PMID:  8385525     Owner:  NLM     Status:  MEDLINE    
Although lisinopril and enalapril are equipotent angiotensin converting enzyme (ACE) inhibitors lisinopril has been reported to produce greater inhibition of plasma ACE 24 hours after single doses. This study compared the antihypertensive effects of once daily 10mg doses of the drugs using a randomised, double-blind, two period cross-over design with ambulatory blood pressure monitoring. Lisinopril lowered mean 24 hour systolic blood pressure significantly more than enalapril after 4 weeks of treatment (14/7 +/- 2/1mmHg & 9/6 +/- 2/1mmHg, respectively, adjusted SBP difference 4.8mmHg, P < 0.01). This difference was confined to the second 12 hours of the daily dosage interval (adjusted SBP difference 13-24 hours after dosing 9.9mmHg, P < 0.001). The diastolic pressure showed a similar trend but this was not statistically significant. The side effects of each agent were minor. We conclude that chronic, once daily therapy with 10mg of lisinopril reduces systolic blood pressure more effectively than an equal dose of enalapril due to its greater effect in the latter half of the 24 hour dosage interval.
S Gourlay; J McNeil; A Forbes; B McGrath
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  15     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-05-11     Completed Date:  1993-05-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-89     Citation Subset:  IM    
Dept of Social & Preventive Medicine, Monash Medical School, Alfred Hospital, Prahran Victoria, Australia.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / administration & dosage,  therapeutic use
Antihypertensive Agents / administration & dosage,  therapeutic use
Blood Pressure Monitors
Diastole / drug effects
Dipeptides / administration & dosage,  therapeutic use*
Double-Blind Method
Enalapril / administration & dosage,  therapeutic use*
Hypertension / drug therapy*,  physiopathology
Middle Aged
Systole / drug effects
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Dipeptides; 75847-73-3/Enalapril; 83915-83-7/Lisinopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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