Document Detail

Differences in the accumulation of mitochondrial defects with age in mice and humans.
MedLine Citation:
PMID:  22015485     Owner:  NLM     Status:  MEDLINE    
Mitochondrial DNA mutations and associated defects in cytochrome c oxidase (COX) are proposed to play an important role in human ageing; however there have been limited studies on the frequency of these defects in normal mouse ageing. Here we compare COX-deficiency in two epithelial tissues; the colon and the ciliary epithelium, from human and mouse. The pattern of accumulation of COX-deficiency is similar in both tissues in the two species; however the frequency of colonic crypts with COX-deficiency in aged humans is significantly higher than in aged mice, whereas the levels of COX-deficiency in the ciliary epithelium are higher in the mouse than in humans. This suggests the impact of mitochondrial defects on normal ageing may differ significantly between species.
Laura C Greaves; Martin J Barron; George Campbell-Shiel; Thomas B L Kirkwood; Douglass M Turnbull
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-12
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  132     ISSN:  1872-6216     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:    2011 Nov-Dec
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-04-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  588-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Aging / genetics*,  metabolism*
Colon / enzymology
Cytochrome-c Oxidase Deficiency / genetics*
DNA, Mitochondrial / genetics*
Mice, Inbred C57BL
Pigment Epithelium of Eye / enzymology
Species Specificity
Grant Support
G0601943//Medical Research Council; G0700718//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council
Reg. No./Substance:
0/DNA, Mitochondrial

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