| Differences in accessory pathway location by sex and race. | |
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MedLine Citation:
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PMID: 19914144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The etiology of accessory pathway (AP) formation is generally unknown. OBJECTIVE: The purpose of this study was to test the hypothesis that AP formation is genetically mediated by examining whether AP location differs by sex and/or race, using sex and race as proxies to distinguish genetically different individuals. METHODS: This was a single-center, retrospective cohort study of 282 consecutive patients undergoing their first electrophysiology study that revealed at least one AP between 2004 and 2008. Sex and race were compared with AP location determined by invasive electrophysiology study. RESULTS: Eighty-nine (52%) males and 40 (36%) females had a left posterior AP (P = .006). Sixty-four (57%) females had a right annular AP, compared with 55 (32%) males (P <.001). After adjusting for age and race, females had 2.8-fold greater odds of having a right annular AP compared with males (95% confidence interval [CI] 1.70-4.65 greater odds; P <.001). While right anterior (free-wall) pathways were rare in all other races (12%), a significantly larger proportion of Asians (n = 10, 26%) had a right anterior AP (P = .017). After adjusting for sex and age, Asians had 3.8-fold greater odds of having a right anterior AP compared with other races (95% CI 1.5-9.4 greater odds; P = .004). CONCLUSIONS: Females more commonly had right annular APs, and Asians had right anterior APs substantially more frequently than other races. These findings suggest that the pathogenesis of AP formation may have a genetic component. |
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Authors:
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Jonathan C Hsu; Ronn E Tanel; Byron K Lee; Melvin M Scheinman; Nitish Badhwar; Randall J Lee; Zian H Tseng; Jeffrey E Olgin; Gregory M Marcus |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2009-09-19 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 7 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2011-03-22 Revised Date: 2011-07-19 |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 52-6 Citation Subset: IM |
Affiliation:
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University of California, San Francisco, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Accessory Atrioventricular Bundle
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epidemiology*,
genetics Adolescent Adult California / epidemiology Child Cohort Studies Confidence Intervals Continental Population Groups* Electrophysiologic Techniques, Cardiac Female Heart Conduction System / pathology* Humans Male Odds Ratio Retrospective Studies Sex Factors Tachycardia, Atrioventricular Nodal Reentry / epidemiology, genetics Tachycardia, Reciprocating / epidemiology, genetics Wolff-Parkinson-White Syndrome / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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KL2 RR024130/RR/NCRR NIH HHS; L30 HL078035-01/HL/NHLBI NIH HHS; L30 HL078035-02/HL/NHLBI NIH HHS; L30 HL078035-03/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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