Document Detail


Differences in white matter fiber tract development present from 6 to 24 months in infants with autism.
MedLine Citation:
PMID:  22362397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Evidence from prospective studies of high-risk infants suggests that early symptoms of autism usually emerge late in the first or early in the second year of life after a period of relatively typical development. The authors prospectively examined white matter fiber tract organization from 6 to 24 months in high-risk infants who developed autism spectrum disorders (ASDs) by 24 months.
METHOD: The participants were 92 high-risk infant siblings from an ongoing imaging study of autism. All participants had diffusion tensor imaging at 6 months and behavioral assessments at 24 months; a majority contributed additional imaging data at 12 and/or 24 months. At 24 months, 28 infants met criteria for ASDs and 64 infants did not. Microstructural properties of white matter fiber tracts reported to be associated with ASDs or related behaviors were characterized by fractional anisotropy and radial and axial diffusivity.
RESULTS: The fractional anisotropy trajectories for 12 of 15 fiber tracts differed significantly between the infants who developed ASDs and those who did not. Development for most fiber tracts in the infants with ASDs was characterized by higher fractional anisotropy values at 6 months followed by slower change over time relative to infants without ASDs. Thus, by 24 months of age, those with ASDs had lower values.
CONCLUSIONS: These results suggest that aberrant development of white matter pathways may precede the manifestation of autistic symptoms in the first year of life. Longitudinal data are critical to characterizing the dynamic age-related brain and behavior changes underlying this neurodevelopmental disorder.
Authors:
Jason J Wolff; Hongbin Gu; Guido Gerig; Jed T Elison; Martin Styner; Sylvain Gouttard; Kelly N Botteron; Stephen R Dager; Geraldine Dawson; Annette M Estes; Alan C Evans; Heather C Hazlett; Penelope Kostopoulos; Robert C McKinstry; Sarah J Paterson; Robert T Schultz; Lonnie Zwaigenbaum; Joseph Piven;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  169     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-08-16     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-600     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Anisotropy
Autistic Disorder / etiology,  pathology*
Brain / growth & development,  pathology*
Case-Control Studies
Child Development Disorders, Pervasive / etiology,  pathology
Child, Preschool
Diffusion Tensor Imaging
Female
Humans
Infant
Magnetic Resonance Imaging
Male
Nerve Fibers, Myelinated / pathology*
Neuroimaging
Grant Support
ID/Acronym/Agency:
EB-005149/EB/NIBIB NIH HHS; HD-03110/HD/NICHD NIH HHS; HD-055741/HD/NICHD NIH HHS; HD-055741-S1/HD/NICHD NIH HHS; HD-40127/HD/NICHD NIH HHS; P30 HD003110/HD/NICHD NIH HHS; P30 HD003110-40/HD/NICHD NIH HHS; R01 HD055741/HD/NICHD NIH HHS; R01 HD055741-01/HD/NICHD NIH HHS; R01 HD055741-02S1A1/HD/NICHD NIH HHS; T32 HD007376/HD/NICHD NIH HHS; T32 HD040127/HD/NICHD NIH HHS; T32 HD040127-10/HD/NICHD NIH HHS; U54 EB005149/EB/NIBIB NIH HHS; U54 EB005149-07/EB/NIBIB NIH HHS
Investigator
Investigator/Affiliation:
J Piven / ; H C Hazlett / ; C Chappell / ; S R Dager / ; A M Estes / ; D Shaw / ; K N Botteron / ; R C McKinstry / ; J Constantino / ; J Pruett / ; R T Schultz / ; S J Paterson / ; L Zwaigenbaum / ; A C Evans / ; D L Collins / ; G B Pike / ; P Kostopoulos / ; S Das / ; G Gerig / ; M Styner / ; H Gu / ; P Sullivan / ; F Wright /
Comments/Corrections
Comment In:
Am J Psychiatry. 2012 Jun;169(6):551-3   [PMID:  22684588 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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