Document Detail


Differences in vascular nitric oxide and endothelium-derived hyperpolarizing factor bioavailability in blacks and whites.
MedLine Citation:
PMID:  24675657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Abnormalities in nitric oxide (NO) bioavailability have been reported in blacks. Whether there are differences in endothelium-derived hyperpolarizing factor (EDHF) in addition to NO between blacks and whites and how these affect physiological vasodilation remain unknown. We hypothesized that the bioavailability of vascular NO and EDHF, at rest and with pharmacological and physiological vasodilation, varies between whites and blacks.
APPROACH AND RESULTS: In 74 white and 86 black subjects without known cardiovascular disease risk factors, forearm blood flow was measured using plethysmography at rest and during inhibition of NO with N(G)-monomethyl-L-arginine and of K(+) Ca channels (EDHF) with tetraethylammonium. The reduction in resting forearm blood flow was greater with N(G)-monomethyl-L-arginine (P=0.019) and similar with tetraethylammonium in whites compared with blacks. Vasodilation with bradykinin, acetylcholine, and sodium nitroprusside was lower in blacks compared with whites (all P<0.0001). Inhibition with N(G)-monomethyl-L-arginine was greater in whites compared with blacks with bradykinin, acetylcholine, and exercise. Inhibition with tetraethylammonium was lower in blacks with bradykinin, but greater during exercise and with acetylcholine.
CONCLUSIONS: The contribution to both resting and stimulus-mediated vasodilator tone of NO is greater in whites compared with blacks. EDHF partly compensates for the reduced NO release in exercise and acetylcholine-mediated vasodilation in blacks. Preserved EDHF but reduced NO bioavailability and sensitivity characterizes the vasculature in healthy blacks.
CLINICAL TRIAL REGISTRATION URL: http://clinicaltrials.gov/. Unique identifier: NCT00166166.
Authors:
Muhiddin A Ozkor; Ayaz M Rahman; Jonathan R Murrow; Nino Kavtaradze; Ji Lin; Amita Manatunga; Salim Hayek; Arshed A Quyyumi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2014-03-27
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  34     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-05-15     Completed Date:  2014-07-10     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1320-7     Citation Subset:  IM    
Copyright Information:
© 2014 American Heart Association, Inc.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00166166
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Adult
African Americans
Biological Availability
Biological Factors / physiology*
Bradykinin / pharmacology
European Continental Ancestry Group
Exercise
Female
Forearm / blood supply
Humans
Male
Middle Aged
Nitric Oxide / physiology*
Nitroprusside / pharmacology
Potassium Channels, Calcium-Activated / physiology
Tetraethylammonium Compounds / pharmacology
Vascular Resistance / drug effects
Vasodilation / drug effects,  physiology*
omega-N-Methylarginine / pharmacology
Grant Support
ID/Acronym/Agency:
R01 HL079115/HL/NHLBI NIH HHS; R01 HL79115/HL/NHLBI NIH HHS; UL1TR000454/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Factors; 0/Potassium Channels, Calcium-Activated; 0/Tetraethylammonium Compounds; 0/endothelium-dependent hyperpolarization factor; 169D1260KM/Nitroprusside; 27JT06E6GR/omega-N-Methylarginine; 31C4KY9ESH/Nitric Oxide; N9YNS0M02X/Acetylcholine; S8TIM42R2W/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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