Document Detail


Differences in diffusion of FDA antidepressant risk warnings across racial-ethnic groups.
MedLine Citation:
PMID:  23412363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE Numerous articles have identified that medical technologies diffuse more rapidly among non-Latino whites compared with other racial-ethnic groups. However, whether health risk warnings also diffuse differentially across racial-ethnic minority groups is uncertain. This study assessed racial-ethnic variation in children's antidepressant use before and after the 2004 black-box warning concerning risks of antidepressants for youths. METHODS Data consisted of responses for white, black, and Latino youths ages five through 17 from the 2002-2008 Medical Expenditure Panel Survey (N=44,422). The dependent variable was any antidepressant use in the prior year. Independent variables were race-ethnicity, year, psychological impairment, income, insurance status, region, and parents' education level. Logistic regression models were used to assess antidepressant use conditional on race-ethnicity, time, interaction between race-ethnicity and time, need, socioeconomic status, and Institute of Medicine-concordant estimates of disparities in predicted antidepressant use before and after the warning. RESULTS The warnings affected antidepressant use differentially for whites, blacks, and Latinos. Usage rates among whites decreased from 3.3 to 2.1 percentage points between prewarning and postwarning, whereas usage rates remained steady among Latinos and increased among blacks. Findings were significant in multiple regression analyses, in which predictions were adjusted for need. CONCLUSIONS The findings indicate that health safety information on antidepressant usage among children diffused faster among whites than nonwhites, suggesting the need to improve infrastructure for delivering important health messages to racial-ethnic minority populations.
Authors:
Andrea Elizabeth DePetris; Benjamin L Cook
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Psychiatric services (Washington, D.C.)     Volume:  64     ISSN:  1557-9700     ISO Abbreviation:  Psychiatr Serv     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-01     Completed Date:  2013-12-26     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  9502838     Medline TA:  Psychiatr Serv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  466-71, 471.e1-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
African Americans / education,  statistics & numerical data
Antidepressive Agents / adverse effects*,  therapeutic use
Child
Child, Preschool
Drug Labeling / statistics & numerical data*
Ethnic Groups / education,  statistics & numerical data*
European Continental Ancestry Group / education,  statistics & numerical data
Female
Hispanic Americans / education,  statistics & numerical data
Humans
Information Dissemination*
Logistic Models
Male
Patient Education as Topic / statistics & numerical data*
United States
United States Food and Drug Administration
Grant Support
ID/Acronym/Agency:
R01 MH091042/MH/NIMH NIH HHS; R01 MH091042/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents
Comments/Corrections

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