| Differences in CEA values determined by EIA and RIA in patients with benign and malignant biliary obstructions. | |
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MedLine Citation:
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PMID: 3887894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serial carcinoembryonic antigen (CEA) levels were determined by both the Roche RIA and Abbott EIA methods in 11 patients with pancreatic cancer (9 with extrahepatic biliary obstruction); 7 with benign extrahepatic obstruction; 26 with colonic cancer without biliary obstruction; and 12 normal, non-smoking controls. The Roche/Abbott CEA ratios in the patients with malignant and benign obstruction (mean ratios = 3.05 and 3.08, respectively), were significantly higher than those in patients with colon cancer without biliary obstruction and in normal controls (mean ratios = 1.35 and 1.06, respectively). Four patients with malignant obstructions were decompressed successfully (bilirubin less than or equal to 1.5 mg/dL); the ratios for two of these patients declined to "normal" (1.0), while the ratios for the other two remained elevated despite decompression. These findings show that some patients with benign or malignant biliary obstruction have elevated CEA levels when measured by the Roche RIA but not with the Abbott EIA. |
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Authors:
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E Scapa; D E Haagensen; W Cantarow; M S Loewenstein; P Thomas; N Zamcheck |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of clinical pathology Volume: 83 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1985 May |
Date Detail:
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Created Date: 1985-06-07 Completed Date: 1985-06-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 589-93 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoembryonic Antigen / analysis* Cholestasis, Extrahepatic / immunology* Colonic Neoplasms / immunology Female Gallstones / immunology Humans Immunoenzyme Techniques Male Middle Aged Pancreatic Neoplasms / immunology Radioimmunoassay Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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CA-04486/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinoembryonic Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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