Document Detail


Differences in Brain Natriuretic Peptide Value between Transient Ischemic Attack and Stroke Patients with Atrial Fibrillation.
MedLine Citation:
PMID:  22024997     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose: The present study investigated clinical characteristics including plasma brain natriuretic peptide (BNP) among transient ischemic attack (TIA) and stroke patients with atrial fibrillation (AF). Methods: We prospectively enrolled 227 consecutive patients with AF within 24 h of onset of TIA or stroke, and plasma BNP was measured on admission. Patients were divided into 2 groups: TIA and stroke groups. The factors associated with TIA were investigated by multivariate logistic regression analysis. Results: 21 patients (9.3%) were diagnosed with TIA, and 206 patients (90.7%) with stroke. The plasma BNP level of the TIA group was significantly lower than that of the stroke group [median (interquartile range) 86.5 (72.7-189.0) pg/ml vs. 269.0 (146.0-432.0) pg/ml, p = 0.0002]. The optimal cutoff level, sensitivity, and specificity of BNP levels to distinguish the TIA group from the stroke group were 120 pg/ml, 79.1 and 66.7%, respectively. Multivariate logistic regression analysis demonstrated that pre-admission warfarin use (OR 3.7; 95% CI 1.178-11.570, p = 0.0250), glucose of ≤120 mg/dl (OR 5.1; 95% CI 1.629-16.238, p = 0.0052) and a plasma BNP of ≤120 pg/ml (OR 6.1; 95% CI 1.967-18.931, p = 0.0017) were independently associated with TIA. Conclusions: In AF patients, the BNP value on admission is lower in those with TIA than in those with stroke. Thus, cardiac function may be associated with neurological severity at the onset of TIA and stroke.
Authors:
Kensaku Shibazaki; Kazumi Kimura; Yasuyuki Iguchi; Junya Aoki; Kenichiro Sakai; Kazuto Kobayashi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  European neurology     Volume:  66     ISSN:  1421-9913     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  271-276     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Stroke Medicine, Kawasaki Medical School, Kurashiki City, Japan.
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