Document Detail

Differences in the association between serum leptin levels and body mass index in black and white women: a report from the Southern Community Cohort Study.
MedLine Citation:
PMID:  22353927     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Leptin may be an important link between obesity and many high-burden diseases, including cancer and cardiovascular disease, but leptin levels and correlates in individuals of diverse racial backgrounds have not been well characterized despite racial differences in incidence and mortality patterns for many obesity-related diseases.
METHODS: In a cross-sectional study of 915 white and 892 black women enrolled in the Southern Community Cohort Study (age 40-79 years, half postmenopausal), serum leptin levels were compared between the race groups and across categories of body mass index (BMI). Potential correlates of leptin were assessed via race-stratified linear regression models.
RESULTS: Blacks had higher unadjusted leptin levels than whites (geometric mean 22.4 vs. 19.0 ng/ml; p < 0.0001). Leptin increased with increasing BMI, and racial differences in leptin were most pronounced in women with BMI ≥25. Significant correlates of leptin included BMI, age, alcohol consumption, cigarette smoking, diabetes (both races) and fat consumption (black women only). Leptin remained higher in black women (22.7 vs. 18.8 ng/ml) after adjustment for these factors.
CONCLUSIONS: Persistent racial differences in leptin concentrations exist after adjustment for BMI and other factors. Leptin assessment may be informative in future studies that investigate racial differences in the development of obesity-related diseases.
Sarah S Cohen; Jay H Fowke; Qiuyin Cai; Maciej S Buchowski; Lisa B Signorello; Margaret K Hargreaves; Wei Zheng; William J Blot; Charles E Matthews
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-18
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  60     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-15     Completed Date:  2012-08-10     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  90-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 S. Karger AG, Basel.
International Epidemiology Institute, Rockville, MD, USA.
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MeSH Terms
African Continental Ancestry Group
Age Factors
Alcohol Drinking
Biological Markers / blood
Body Mass Index
Cohort Studies
Community Health Centers
Cross-Sectional Studies
Dietary Fats / administration & dosage
European Continental Ancestry Group
Leptin / blood*
Middle Aged
Obesity / blood,  ethnology
Overweight / blood*,  ethnology
Prospective Studies
Southeastern United States
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats; 0/Leptin

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