Document Detail


Differences in the association between maternal serum homocysteine and ADMA levels in women with pregnancies complicated by preeclampsia and/or intrauterine growth restriction.
MedLine Citation:
PMID:  23273067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The aim of our study was to investigate the association between homocysteine and asymmetric dimethylarginine in preeclamptic women with and without intrauterine growth restriction compared with normal healthy uncomplicated pregnancies and normotensive pregnancies complicated by idiopathic isolated intrauterine fetal growth restriction.
METHODS: The maternal serum homocysteine and asymmetric dimethylarginine concentrations were determined using a sandwich enzyme-linked immunosorbent assays.
RESULTS: A statistically significant positive correlation of maternal serum homocysteine levels with the serum asymmetric dimethylarginine levels was observed in healthy normotensive uncomplicated pregnant women from the control group and in preeclamptic patients with appropriate-for-gestational-age fetuses (R = 0.380079, p-value = 0.002311* and R = 0.455797, p-value = 0.004030* for the control and the P groups, respectively). However, this correlation was not significant in women with pregnancy complicated by intrauterine growth restriction, both isolated and in the course of severe preeclampsia.
CONCLUSION: These findings provide support for the hypothesis that elevated levels of asymmetric dimethylarginine in pregnancy complicated by preeclampsia are associated with elevated homocysteine levels. But our results also demonstrate that in pregnancies complicated by intrauterine growth restriction, this mechanism is important, although not the only one.
Authors:
Marzena Laskowska; Katarzyna Laskowska; Jan Oleszczuk
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Publication Detail:
Type:  Journal Article     Date:  2012-12-28
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  32     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2013  
Date Detail:
Created Date:  2013-02-11     Completed Date:  2014-04-22     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arginine / analogs & derivatives*,  blood
Case-Control Studies
Female
Fetal Growth Retardation / blood*,  etiology
Homocysteine / blood*
Humans
Pre-Eclampsia / blood*,  etiology
Pregnancy
Young Adult
Chemical
Reg. No./Substance:
0LVT1QZ0BA/Homocysteine; 30315-93-6/N,N-dimethylarginine; 94ZLA3W45F/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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