| Differences in Angiotensin Convertase Enzyme (ACE) Activity and Expression May Contribute to Shorter Event Free Period After Coronary Artery Bypass Graft Surgery. | |
| | |
MedLine Citation:
|
PMID: 21106034 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Aims: The goal of this study was to investigate the importance of the vascular angiotensin convertase enzyme (ACE) in coronary artery bypass graft surgery (CABG) patients. Methods: Vascular tissue (distal saphenous vein [n= 163] and/or radial artery [n= 120] segments) and blood samples were collected from CABG patients (n= 81). We studied (i) the potency of angiotensin I (AngI) and angiotensin II (AngII) to evoke vascular contractions; (ii) vascular and plasma ACE concentrations; and (iii) ACE genotype of the patients enrolled. Results: The ratio of the potencies (EC(50) ) of AngII and AngI was significantly lower in radial artery compared to the saphenous vein (0.17 ± 0.03 nM and 0.51 ± 0.14 nM, respectively, P= 0.003), suggesting a 3-fold more effective AngI conversion in saphenous vein samples. Angiotensin constrictions were inhibited with telmisartan and captopril in both saphenous veins and radial arteries. Vascular ACE expression was significantly higher in saphenous vein compared to radial artery (9.7 ± 1.0 ng/mg and 5.3 ± 0.7 ng/mg, respectively, P= 0.01). Serum but no tissue ACE concentration was determined by ACE insertion/deletion polymorphism. Accordingly, no relation was found between serum and tissue ACE expression. Conclusion: ACE-inhibitor therapy targeting tissue located ACE may be beneficial to patients with saphenous vein grafts after CABG surgery. |
| | |
Authors:
|
Andrea Daragó; Miklós Fagyas; Ivetta M Siket; Andrea Facskó; Zita Megyesi; Judit Kalász; Zoltán Galajda; Tamás Szerafin; Jolán Hársfalvi; István Edes; Zoltán Papp; Attila Tóth; József Szentmiklósi |
Related Documents
:
|
300824 - Anomalous origin of left coronary artery from pulmonary artery. case report and review ... 7728804 - Glycosaminoglycan distribution in atherosclerotic saphenous vein grafts. 16698704 - A modified technique for bypass of the external carotid artery to the proximal posterio... 9033314 - Surgical preparation abolishes endothelium-derived hyperpolarizing factor-mediated hype... 8456384 - Blade-deviated fenestrated clips for anterior communicating artery aneurysms. 6840144 - Angiographic findings in relation to clinical course and results of computed tomography... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-25 |
Journal Detail:
|
Title: Cardiovascular therapeutics Volume: 30 ISSN: 1755-5922 ISO Abbreviation: Cardiovasc Ther Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-05-04 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
|
Languages: eng Pagination: 136-44 Citation Subset: IM |
Copyright Information:
|
© 2010 Blackwell Publishing Ltd. |
Affiliation:
|
Institute of Cardiology, University of Debrecen, Debrecen, Hungary Department of Ophthalmology, University of Debrecen, Debrecen, Hungary Clinical Research Center, University of Debrecen, Debrecen, Hungary Institute of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Aliskiren in the treatment of hypertension and organ damage.
Next Document: Heat and moisture exchangers and breathing system filters: their use in anaesthesia and intensive ca...