Document Detail


Differences detected in vivo between samples of aflatoxin-contaminated peanut meal, following decontamination by two ammonia-based processes.
MedLine Citation:
PMID:  11288911     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A sample of peanut meal, highly contaminated with aflatoxins, has been subjected to decontamination by two commercial ammonia-based processes. The original contaminated and the two decontaminated meals were fed to rats for 90 days. No lesions associated with aflatoxin-induced hepatocarcinogenesis were detected histologically following feeding with the two detoxified meals. There were, however, clear differences between the two meals in respect of growth rates of the rats. In addition, feeding one of the detoxified meals resulted in hepatic abnormalities detected using novel immunohistochemical reagents. Differences between the two detoxified meals were also indicated by the results of studies using meals 'spiked' with [14C]-aflatoxin B1 prior to being subjected to the detoxification processes. The meals differed in the bioavailability of the label. It was concluded that peanut meal where an initial, unacceptable level of contamination with aflatoxins had been reduced by two ammonia-based processes to comparable, acceptable levels, may still have different effects in vivo when incorporated into animal diets.
Authors:
G E Neal; D J Judah; P Carthew; A Verma; I Latour; L Weir; R D Coker; M J Nagler; L A Hoogenboom
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Food additives and contaminants     Volume:  18     ISSN:  0265-203X     ISO Abbreviation:  Food Addit Contam     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-04-05     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-49     Citation Subset:  IM    
Affiliation:
MRC Toxicology Unit, University of Leicester, UK. neal@merstham95.fsnet.co.uk
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MeSH Terms
Descriptor/Qualifier:
Aflatoxins / pharmacokinetics,  toxicity*
Ammonia*
Animals
Arachis hypogaea*
Biological Availability
Decontamination / methods
Eating / drug effects
Food Contamination*
Immunoenzyme Techniques
Kidney / pathology
Liver / pathology
Liver Neoplasms / chemically induced
Male
Organ Size / drug effects
Rats
Rats, Inbred F344
Weight Gain / drug effects
Chemical
Reg. No./Substance:
0/Aflatoxins; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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