| Differences between left and right ventricular anatomy determine the types of reentrant circuits induced by an external electric shock. A rabbit heart simulation study. | |
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MedLine Citation:
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PMID: 16055175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the fact that elucidating the mechanisms of cardiac vulnerability to electric shocks is crucial to understanding why defibrillation shocks fail, important aspects of cardiac vulnerability remain unknown. This research utilizes a novel anatomically based bidomain finite-element model of the rabbit ventricles to investigate the effect of shock polarity reversal on the reentrant activity induced by an external defibrillation-strength shock in the paced ventricles. The specific goal of the study is to examine how differences between left and right ventricular chamber anatomy result in differences in the types of reentrant circuits established by the shock. Truncated exponential monophasic shocks of duration 8 ms were delivered via two external electrodes at various timings. Vulnerability grids were constructed for shocks of reversed polarity (referred to as RV- or LV- when either the RV or the LV electrode is a cathode). Our results demonstrate that reversing electrode polarity from RV- to LV- changes the dominant type of post-shock reentry: it is figure-of-eight for RV- and quatrefoil for LV- shocks. Differences in secondary types of post-shock arrhythmia also occur following shock polarity reversal. These effects of polarity reversal are primarily due to the fact that the LV wall is thicker than the RV, resulting in a post-shock excitable gap that is predominantly within the LV wall for RV- shocks and in the septum for LV- shocks. |
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Authors:
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Blanca Rodríguez; James C Eason; Natalia Trayanova |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2005-07-11 |
Journal Detail:
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Title: Progress in biophysics and molecular biology Volume: 90 ISSN: 0079-6107 ISO Abbreviation: Prog. Biophys. Mol. Biol. Publication Date: 2006 Jan-Apr |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-04-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0401233 Medline TA: Prog Biophys Mol Biol Country: England |
Other Details:
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Languages: eng Pagination: 399-413 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Lindy Boggs Center, Tulane University, Suite 500, Tulane University, New Orleans, LA 70118, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / physiopathology Defibrillators Heart Ventricles / anatomy & histology Models, Cardiovascular* Rabbits Ventricular Function* |
| Grant Support | |
ID/Acronym/Agency:
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HL063196/HL/NHLBI NIH HHS; HL067322/HL/NHLBI NIH HHS; P20 EB001432/EB/NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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