| Differences between individuals with hemoglobins Istanbul and Saint-Etienne (alpha 2 beta 2 92F8 His replaced by Gln). | |
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MedLine Citation:
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PMID: 111458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unstable hemoglobins Istanbul and Saint-Etienne have the same amino acid substitution (alpha 2 beta 2 92F8 His leads to Gln). Despite this, there are some clinical and hematological differences between the individual with Hb Istanbul and the one with Hb Saint-Etienne. These are: (1) the clinical course of the patient with Hb Istanbul before splenectomy was more severe when compared with that of the individual with Hb Saint-Etienne; (2) although Hb F was found within normal range in the individual with Hb Istanbul, a high level of Hb F (19%) was observed in the patient with Hb Saint-Etienne. The alkali-resistant Hb found in the former was of adult type and in the latter case it was of fetal type. The possible explanations for these differences are discussed. |
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Authors:
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M Aksoy; S Erdem |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta haematologica Volume: 61 ISSN: 0001-5792 ISO Abbreviation: Acta Haematol. Publication Date: 1979 |
Date Detail:
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Created Date: 1979-09-27 Completed Date: 1979-09-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0141053 Medline TA: Acta Haematol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 295-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / blood Child Fetal Hemoglobin* / analysis, genetics Hemoglobins, Abnormal* / analysis, genetics Humans Male Mutation Splenectomy |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Hemoglobins, Abnormal; 9034-63-3/Fetal Hemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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