Document Detail

Differences between femoral artery and vein smooth muscle cells in volume-regulated chloride channels.
MedLine Citation:
PMID:  23181279     Owner:  NLM     Status:  In-Data-Review    
The purpose of the present study was to compare the differences between the role of volume-regulated Cl(-) channels (VRCCs) in veins and arteries. We used the whole cell patch clamp and fluorescence imaging techniques to evaluate swelling-induced Cl(-) current (I(Cl,vol)) and changes in the intracellular concentrations of Cl(-) ([Cl(-)](i)) induced by hypotonic solutions in rat femoral artery cells (FASMCs) and vein smooth muscle cells (FVSMCs). I(Cl,vol) and [Cl(-)](i) decline induced by hypotonic solution were more prominent in FASMCs than in FVSMCs. I(Cl,vol) and the alterations in [Cl(-)](i) were gradually increased as the number of cell passages increased. However, the regulatory function of tyrosine protein phosphorylation in volume-regulated chloride movement is prominent in veins. The expression of ClC-3 was higher in FASMCs than in FVSMCs. VRCC activity is more pronounced in rat femoral arteries than in veins. VRCC activity and tyrosine protein phosphorylation regulative function increase gradually as vascular cells switch from contractile to proliferative phenotypes.
Xiao-Long Kang; Min Zhang; Jie Liu; Xiao-Fei Lv; Yong-Bo Tang; Yong-Yuan Guan
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Publication Detail:
Type:  Journal Article     Date:  2012-11-07
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  90     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1516-26     Citation Subset:  IM    
a Department of Pharmacology, Vascular Research Center, Zhongshan School of Medicine, Sun Yat-Sen University, 74 Zhongshan 2 Road, Guangzhou 510089, People's Republic of China.
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