| Differences between the effects of indorenate and other 5-HT1A agonists on the rabbit aorta | |
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MedLine Citation:
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PMID: 8678695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine if like buspirone, ipsapirone and 8-hydroxy-2(di-N-propylamino)tetralin (8-OH-DPAT), the alpha 1-adrenoceptors are involved in the responses elicited by indorenate in rabbit aorta. Exception made of ipsapirone, all the 5-HT1A agonists above mentioned contracted aortic rings. The contraction elicited by buspirone and 8-OH-DPAT was blocked with prazosin (alpha 1-adrenergic antagonist), whereas the effect of indorenate was unaffected with this blocker but it was inhibited with ritanserin (5-HT2 antagonist). On the other hand, buspirone, ipsapirone and 8-OH-DPAT but not indorenate relaxed arteries precontracted with methoxamine (alpha 1-adrenergic agonist) and none of the agonists relaxed preparations precontracted with acetylcholine or KCl. The results indicate that buspirone and 8-OH-DPAT are partial alpha 1-adrenoceptor agonists since they elicited contractions which are blocked with prazosin and relaxed only rings precontracted with methoxamine. Ipsapirone behaved as an alpha 1-adrenoceptor antagonist since it showed the relaxant but not the contractile effect. Finally, we found no evidence that indorenate has afinity for alpha 1-adrenoceptors. Contraction elicited by this agonist seems to be mediated by 5-HT2 receptors, inasmuch it was blocked with ritanserin. |
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Authors:
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C Castillo; M A Rosas-Lezama; E F Castillo; F J Larios; E Hong |
Publication Detail:
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Type: Comparative Study; English Abstract; In Vitro; Journal Article |
Journal Detail:
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Title: Archivos del Instituto de Cardiología de México Volume: 65 ISSN: 0020-3785 ISO Abbreviation: Arch Inst Cardiol Mex Publication Date: 1995 Sep-Oct |
Date Detail:
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Created Date: 1996-08-15 Completed Date: 1996-08-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400463 Medline TA: Arch Inst Cardiol Mex Country: MEXICO |
Other Details:
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Languages: spa Pagination: 395-402 Citation Subset: IM |
Affiliation:
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Departamento de Fisiología y Farmacología, Escuela Superior de Medicina, I.P.N., México, D.F. |
Vernacular Title:
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Diferencias entre los efectos del indorrenato y otros agonistas 5-HT1A en la aorta de conejo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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5-Methoxytryptamine
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analogs & derivatives*,
pharmacology Animals Aorta, Thoracic / drug effects*, physiology Dose-Response Relationship, Drug Female Male Muscle Contraction / drug effects Rabbits Receptors, Serotonin / drug effects, physiology Serotonin Agonists / pharmacology* Serotonin Antagonists / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Serotonin Antagonists; 608-07-1/5-Methoxytryptamine; 72318-55-9/indorenate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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