Document Detail


Differences between blacks and whites in the epidemiology of insulin-dependent diabetes mellitus in Allegheny County, Pennsylvania.
MedLine Citation:
PMID:  3456700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Racial differences in the incidence and natural history of insulin-dependent diabetes mellitus were evaluated in Allegheny County, Pennsylvania. The yearly incidence rate for whites was approximately 1.5 times that for blacks. The cumulative risk of developing insulin-dependent diabetes prior to age 20 was greater for whites (3.1/1,000, males; 2.8/1,000, females) than for blacks (1.7/1,000, males; 2.0/1,000, females). There was a slight excess risk for white males versus white females (relative risk = 1.09, p = 0.04), while no sex differential in risk was noted for blacks. The temporal trends and seasonal patterns were similar. Blacks more frequently possessed human lymphocyte antigen (HLA)-DR3/X and whites DR4/X; however, the risks associated with these antigens were similar by race. At onset, blacks had evidence of greater immunologic disturbance and less frequently reported infection than whites, although blacks more often had evidence of previous coxsackie viral infections. Evaluation of mortality patterns by race revealed that blacks had a higher mortality rate than whites. By 20 years duration of diabetes, blacks had a 2.4-fold increase in the risk of mortality compared with whites.
Authors:
R E LaPorte; N Tajima; J S Dorman; K J Cruickshanks; M S Eberhardt; B S Rabin; R W Atchison; D K Wagener; D J Becker; T J Orchard
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of epidemiology     Volume:  123     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-04-07     Completed Date:  1986-04-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-603     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
African Continental Ancestry Group*
Age Factors
Child
Child, Preschool
Diabetes Mellitus, Type 1 / epidemiology*,  immunology,  mortality
Epidemiologic Methods
European Continental Ancestry Group*
Female
HLA-DR Antigens
Histocompatibility Antigens Class II / isolation & purification
Humans
Immunoglobulins / isolation & purification
Infant
Male
Pennsylvania
Registries
Seasons
Sex Factors
Grant Support
ID/Acronym/Agency:
F32 AM07250/AM/NIADDK NIH HHS; R01 AM24021/AM/NIADDK NIH HHS; R01 AM33226/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/HLA-DR Antigens; 0/Histocompatibility Antigens Class II; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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