| Differences between the O-acetylated sialic acids of the epithelial mucins of human colonic tumors and normal controls: a correlative chemical and histochemical study. | |
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MedLine Citation:
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PMID: 7354217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chemical analyses, together with histochemical assessments, were carried out on specimens of adenocarcinoma of the colon and histologically normal colonic epithelium (from resection margins from cases of carcinoma of the colon). In the epithelial glycoproteins of the normal tissue, both chemical and histochemical investigations indicated that the great majority of the sialic acids contained a side-chain O-acyl substituent located at position C8, whereas the side-chain substitution of the sialic acids of tumor glycoproteins was markedly reduced. Chemical analysis of the normal glycoproteins indicated that the great majority of the sialic acids were resistant to digestion with Vibrio cholerae neuraminidase, presumably due to an ester substituent at C4. The sialic acids of the tumor glycoproteins were significantly different from normal, in that they were less resistant to digestion with neuraminidase (p greater than 0.01), and therefore had a lower percentage of substitution at C4 (p greater than 0.01). |
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Authors:
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P E Reid; C F Culling; W L Dunn; C W Ramey; A B Magil; M G Clay |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Volume: 28 ISSN: 0022-1554 ISO Abbreviation: J. Histochem. Cytochem. Publication Date: 1980 Mar |
Date Detail:
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Created Date: 1980-04-23 Completed Date: 1980-04-23 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9815334 Medline TA: J Histochem Cytochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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analysis* Chemical Phenomena Chemistry Colon / analysis* Colonic Neoplasms / analysis* Epithelium / analysis Glycoproteins / analysis Histocytochemistry Humans Mucins / analysis* Neoplasm Proteins / analysis Neuraminidase / pharmacology Sialic Acids / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Mucins; 0/Neoplasm Proteins; 0/Sialic Acids; EC 3.2.1.18/Neuraminidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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