Document Detail

Difference spectrophotometric assay of 5-hydroxymethylfurfuraldehyde in hydrolysed pharmaceutical syrups--I. Sodium borohydride reagent.
MedLine Citation:
PMID:  16867518     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A rapid difference spectrophotometric procedure is described for the assay of 5-hydroxymethylfurfuraldehyde (5-HMF) in hydrolysed pharmaceutical syrups. The assay involves measurement of the difference absorbance at 283 nm (DeltaA(283)) of a solution of 5-HMF at pH 8 relative to that of an equimolar solution in which the absorption of the 5-HMF has been destroyed by reduction of the carbonyl group by sodium borohydride. The DeltaA(283) is proportional to the concentration of 5-HMF and is unaffected by the presence of sucrose (the sugar component of syrup) or of dextrose or laevulose (the principal sugars of invert syrup). The accuracy, precision and selectivity of the method are discussed. The limits of detection and determination are 0.78 microg ml(-1) and 9.6 microg ml(-1) respectively. The assay has been applied successfully to samples of syrup containing hydroxybenzoate (paraben) preservatives, invert syrup, simple linctus, ephedrine elixir and raspberry syrup.
A G Davidson; T O Dawodu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical and biomedical analysis     Volume:  5     ISSN:  0731-7085     ISO Abbreviation:  J Pharm Biomed Anal     Publication Date:  1987  
Date Detail:
Created Date:  2006-07-26     Completed Date:  2009-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309336     Medline TA:  J Pharm Biomed Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  213-22     Citation Subset:  -    
Department of Pharmacy, University of Strathclyde, George Street, Glasgow G1 1XW, UK.
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