Document Detail

Difference in the time course between increases in coronary flow and in effluent adenosine concentration during anoxia in the perfused rat heart.
MedLine Citation:
PMID:  4087339     Owner:  NLM     Status:  MEDLINE    
The isolated rat heart was perfused by Langendorff's technique with either an oxygenated (95% O2 and 5% CO2) or an anoxic (95% N2 and 5% CO2) solution. Anoxia increased coronary flow and effluent adenosine concentration, but the time course of these changes was discordant; coronary flow increased transiently (the maximum increase in flow was observed within 1-2 min after the onset of anoxia), whereas the effluent adenosine concentration increased as a function of the time during anoxia. The concentration of effluent adenosine reached 3 microM 10 min after anoxia. The tissue (myocardial) adenosine content changed in parallel with the effluent adenosine concentration. An infusion of adenosine increased coronary flow dose-dependently, and the maximum increase was obtained when 0.27 microM of adenosine was infused. Effluent adenosine concentration was 0.05-0.3 microM in both anoxia and adenosine infusion experiments at the time when the maximum increase in coronary flow occurred. An increase in concentrations of adenosine above 0.05-0.03 microM in the effluent was not accompanied by an increase in coronary flow. These results raise a question about the role of adenosine in regulating coronary circulation during anoxic perfusion, though there is a possibility of vasodilatory function of adenosine in early period of anoxic perfusion.
T Ishibashi; K Ichihara; Y Abiko
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  49     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-03-03     Completed Date:  1986-03-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1090-8     Citation Subset:  IM    
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MeSH Terms
Adenosine / analysis*,  pharmacology
Anoxia / metabolism,  physiopathology*
Coronary Circulation*
Dose-Response Relationship, Drug
Myocardium / analysis*
Rats, Inbred Strains
Reg. No./Substance:

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