Document Detail

Difference in sensitivity of the mu and kappa systems in cafeteria rats.
MedLine Citation:
PMID:  6099508     Owner:  NLM     Status:  MEDLINE    
A highly palatable diet (cafeteria diet) provokes an hyperphagia. The effects of Mu and Kappa opiate antagonists (Mu : Naltrexone 0.5 mg/Kg IP; Kappa Mr2266 0.5; 2.5; 10) and agonists (Mu Morphine 0.05; 0.1; 0.5; 2.5; Kappa Mr2033 0.5; 2.5) were studied on the nocturnal food intake of cafeteria rats and chow rats fed with monotonous food. At low doses Mu as well as Kappa antagonists do not modify the food intake of chow rats, but suppress the hyperphagia induced by the cafeteria diet. Kappa agonist provokes a decrease in food intake in chow and cafeteria rats while the Mu agonist at low doses suppresses the hyperphagia induced by cafeteria diet. The involvement of these two opioid systems in this type of hyperphagia is discussed.
A Mandenoff; M C Bertiere; D Betoulle; M Apfelbaum
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuropeptides     Volume:  5     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  265-8     Citation Subset:  IM    
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MeSH Terms
Benzomorphans / pharmacology
Eating* / drug effects
Hyperphagia / etiology
Morphine / pharmacology
Narcotic Antagonists / pharmacology
Rats, Inbred Strains
Receptors, Opioid / drug effects,  physiology*
Receptors, Opioid, kappa
Receptors, Opioid, mu
Reg. No./Substance:
0/Benzomorphans; 0/Narcotic Antagonists; 0/Receptors, Opioid; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 56649-76-4/MR 2266; 57-27-2/Morphine; 57236-85-8/MR 2034

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