| Difference in sensitivity of the mu and kappa systems in cafeteria rats. | |
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MedLine Citation:
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PMID: 6099508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A highly palatable diet (cafeteria diet) provokes an hyperphagia. The effects of Mu and Kappa opiate antagonists (Mu : Naltrexone 0.5 mg/Kg IP; Kappa Mr2266 0.5; 2.5; 10) and agonists (Mu Morphine 0.05; 0.1; 0.5; 2.5; Kappa Mr2033 0.5; 2.5) were studied on the nocturnal food intake of cafeteria rats and chow rats fed with monotonous food. At low doses Mu as well as Kappa antagonists do not modify the food intake of chow rats, but suppress the hyperphagia induced by the cafeteria diet. Kappa agonist provokes a decrease in food intake in chow and cafeteria rats while the Mu agonist at low doses suppresses the hyperphagia induced by cafeteria diet. The involvement of these two opioid systems in this type of hyperphagia is discussed. |
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Authors:
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A Mandenoff; M C Bertiere; D Betoulle; M Apfelbaum |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropeptides Volume: 5 ISSN: 0143-4179 ISO Abbreviation: Neuropeptides Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-04-26 Completed Date: 1985-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8103156 Medline TA: Neuropeptides Country: SCOTLAND |
Other Details:
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Languages: eng Pagination: 265-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzomorphans / pharmacology Diet Eating* / drug effects Humans Hyperphagia / etiology Male Morphine / pharmacology Narcotic Antagonists / pharmacology Rats Rats, Inbred Strains Receptors, Opioid / drug effects, physiology* Receptors, Opioid, kappa Receptors, Opioid, mu |
| Chemical | |
Reg. No./Substance:
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0/Benzomorphans; 0/Narcotic Antagonists; 0/Receptors, Opioid; 0/Receptors, Opioid, kappa; 0/Receptors, Opioid, mu; 56649-76-4/MR 2266; 57-27-2/Morphine; 57236-85-8/MR 2034 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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