Document Detail


Difference in plasminogen activator inhibitor activity between non-Q-wave infarction and Q-wave infarction.
MedLine Citation:
PMID:  8288409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the plasma levels of tissue plasminogen activator antigen and plasminogen activator inhibitor activity in 14 patients with non-Q-wave infarction and in 27 patients with Q-wave infarction before the start of thrombolytic therapy and in 34 control subjects. The mean level of plasma tissue plasminogen activator antigen (ng/ml) was higher (P < 0.01) both in the patients with non-Q-wave infarction and in those with Q-wave infarction than in the control subjects (10.3 +/- 1.9, 9.5 +/- 0.8 vs. 5.8 +/- 0.3), and there was no difference in the level between the patients with non-Q-wave infarction and those with Q-wave infarction. The mean level of plasma plasminogen activator inhibitor activity (IU/ml) was lower (P < 0.01) in the patients with non-Q-wave infarction than in those with Q-wave infarction (7.3 +/- 2.0 vs. 17.1 +/- 2.2), and there was no difference in the level between the patients with non-Q-wave infarction and the control subjects (7.3 +/- 2.0 vs. 4.1 +/- 2.6). The patency rate of infarct-related coronary artery before thrombolytic therapy was higher (P < 0.01) in the patients with non-Q-wave infarction than in those with Q-wave infarction (54% vs. 15%). We conclude that plasminogen activator inhibitor activity was lower in non-Q-wave infarction than in Q-wave infarction and this may be related to the higher patency rate of infarct-related coronary artery in non-Q-wave infarction.
Authors:
H Ogawa; I Misumi; T Sakamoto; T Masuda; H Okubo; Y Miyao; H Yasue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  41     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  201-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Kumamoto University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty
Antigens / blood
Coronary Angiography
Electrocardiography*
Female
Fibrinolysis / physiology
Humans
Male
Middle Aged
Myocardial Infarction / blood*,  classification,  therapy
Plasminogen Activators / immunology
Plasminogen Inactivators / blood*
Thrombolytic Therapy
Urokinase-Type Plasminogen Activator / therapeutic use
Vascular Patency
Chemical
Reg. No./Substance:
0/Antigens; 0/Plasminogen Inactivators; EC 3.4.21.-/Plasminogen Activators; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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