Document Detail


Difference in the expression of alpha 7 nicotinic receptors in the placenta in normal versus severe preeclampsia pregnancies.
MedLine Citation:
PMID:  16837119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The prevalence of preeclampsia is low in smokers, suggesting a possible role of nicotinic receptor in the pathophysiology of the disease. Alpha 7 nicotinic acetylcholine receptor (alpha7 nAChR) was recently found in non-neuronal tissue with various mediating functions. Therefore, we investigated the difference in the placental expression of the alpha7 nAChR in normal versus severe preeclampsia placentas. STUDY DESIGN: Central portions of placenta were obtained from 9 severe preeclampsia women and 11 gestational-age-matched normal pregnant women delivered between the gestational ages of 33 and 40 weeks following elective or emergency cesarean section. RT-PCR, western blotting, and immunohistochemical staining were performed to evaluate the alpha7 nAChR expression difference. RESULTS: In all the placentas, the alpha7 nAChR was expressed in endothelial cells, vascular smooth muscle cells, and stromal cells, but not in trophoblasts. The vascular staining was more intense in the severe preeclampsia placenta (p=0.02). Although the gene expression did not differ between the two groups, protein expression was greater in 7 of 9 placenta samples from the severe preeclampsia group. CONCLUSION: Placental expression of alpha7 nAChR differs between normal and severe preeclampsia placentas, suggesting that it may be involved in the pathogenesis of preeclampsia.
Authors:
Ja-Young Kwon; Young-Han Kim; Se-Hoon Kim; Muang-Hwa Kang; Yong-Son Maeng; Kyu-Young Lee; Yong-Won Park
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Publication Detail:
Type:  Journal Article     Date:  2006-07-11
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  132     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-30     Completed Date:  2007-06-26     Revised Date:  2010-06-04    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  35-9     Citation Subset:  IM    
Affiliation:
Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemoon-gu, Seoul 120-752, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blotting, Western
Endothelial Cells / metabolism
Female
Humans
Immunohistochemistry
Muscle, Smooth, Vascular / metabolism
Placenta / anatomy & histology,  metabolism*
Pre-Eclampsia / metabolism*
Pregnancy
Receptors, Nicotinic / genetics,  metabolism*
Reverse Transcriptase Polymerase Chain Reaction
Stromal Cells / metabolism
Up-Regulation
Chemical
Reg. No./Substance:
0/Receptors, Nicotinic; 0/alpha7 nicotinic acetylcholine receptor

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