| Difference in coronary blood flow dynamics between patients with hypertension and those with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 12452323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied twelve patients with hypertensive left ventricular hypertrophy (LVH), 10 patients with hypertrophic cardiomyopathy (HCM) and 10 control subjects to examine the differences in coronary blood flow (CBF) dynamics between patients with hypertensive LVH and those with HCM. All subjects had normal coronary arteriograms. Measurements of CBF using Doppler Flo-Wire were performed at rest, and after infusions of acetylcholine and papaverine. The baseline CBF was significantly increased in both hypertensive LVH patients and HCM patients compared to that noted in control subjects (64.1+/-36.9, 80.0+/-38.1, 32.3+/-8.0 ml/min, respectively, p<0.01). Coronary flow reserve and endothelium-dependent vasodilatation were significantly lower in hypertensive LVH patients and HCM patients than in control subjects, but there was no significant difference between the hypertensive LVH and HCM patients themselves. In contrast, the diastolic/systolic velocity ratio at baseline was significantly lower in hypertensive LVH patients than in HCM patients (1.53+/-0.40, 6.31+/-7.50, p<0.05). Although CBF and coronary flow reserve correlated positively and negatively, respectively, with left ventricular mass index (r=0.51, -0.59, respectively), the diastolic/systolic velocity ratio at baseline did not show a significant correlation to left ventricular mass index. In conclusion, the diastolic/systolic velocity ratio differed between hypertensive LVH and HCM patients, independent of left ventricular mass. These results suggest that the difference of phasic pattern of CBF may be essential for coronary circulation in patients with hypertensive LVH and in those with HCM. |
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Authors:
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Katsushi Misawa; Yutaka Nitta; Takao Matsubara; Kotaro Oe; Masaru Kiyama; Masami Shimizu; Hiroshi Mabuchi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 25 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 711-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Toyama Red Cross Hospital, Toyama, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity / physiology Cardiomyopathy, Hypertrophic / pathology, physiopathology*, ultrasonography Coronary Circulation / physiology* Diastole / physiology Echocardiography Female Humans Hypertension / physiopathology*, ultrasonography Male Middle Aged Systole / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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