Document Detail


Difference in angiotensinogen haplotype frequencies between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?
MedLine Citation:
PMID:  20945963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was also observed in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, we found the same trend when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF P<0.001; AA vs. DCM P<0.001). These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
Authors:
M Pávková Goldbergová; L Spinarová; J Spinar; J Pařenica; L Sišková; L Groch; J Máchal; A Vašků
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-08-09     Revised Date:  2012-05-31    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Affiliation:
Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic. goldberg@med.muni.cz
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angiotensinogen / genetics*
Atherosclerosis / genetics*
Coronary Disease / genetics
Female
Gene Frequency / genetics*
Genotype
Haplotypes*
Heart Failure / genetics*
Humans
Hypertension / genetics
Male
Middle Aged
Polymorphism, Genetic
Chemical
Reg. No./Substance:
11002-13-4/Angiotensinogen
Comments/Corrections
Comment In:
Physiol Res. 2012;61(2):227   [PMID:  22519460 ]

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