Document Detail

Difference in angiotensinogen haplotype frequencies between chronic heart failure and advanced atherosclerosis patients - new prognostic factor?
MedLine Citation:
PMID:  20945963     Owner:  NLM     Status:  MEDLINE    
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was also observed in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, we found the same trend when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF P<0.001; AA vs. DCM P<0.001). These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes.
M Pávková Goldbergová; L Spinarová; J Spinar; J Pařenica; L Sišková; L Groch; J Máchal; A Vašků
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-15
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  60     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-07     Completed Date:  2011-08-09     Revised Date:  2012-05-31    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Institute of Pathological Physiology, Masaryk University, Brno, Czech Republic.
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MeSH Terms
Aged, 80 and over
Angiotensinogen / genetics*
Atherosclerosis / genetics*
Coronary Disease / genetics
Gene Frequency / genetics*
Heart Failure / genetics*
Hypertension / genetics
Middle Aged
Polymorphism, Genetic
Reg. No./Substance:
Comment In:
Physiol Res. 2012;61(2):227   [PMID:  22519460 ]

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