| Difference in analgesia following epidural blockade in patients with postoperative or chronic low back pain. | |
| | |
MedLine Citation:
|
PMID: 2970056 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Subjective responses of continuous epidural analgesia with bupivacaine were compared in 30 patients with acute (postoperative) or chronic (low back) pain. In the acute pain patients, sensory block was 4 dermatomes at 9 h and 6 dermatomes at 64 h. Corresponding values in the chronic pain patients were 8 and 6 dermatomes respectively. Motor blockade of the lower limbs was more profound in the acute pain group. The acute pain patients had significantly better pain relief (VAS: 85-96% vs. 55-70%) and a significantly higher proportion of these patients reported a global score of 3 (excellent; 80% vs. 7%). The mean dosage of bupivacaine decreased in the acute pain group from 21.0 +/- 5.7 (mean +/- S.D.) mg/h at 9 h to 15.1 +/- 8.5 mg/h at 64 h. Corresponding values for the chronic pain group were 20.7 +/- 5.9 and 12.0 +/- 6.0 mg/h respectively. Mean plasma concentration of bupivacaine increased from 1.2 +/- 0.8 micrograms/ml at 9 h to 2.1 +/- 1.4 micrograms/ml at 64 h in the acute pain patients and was 0.8 +/- 0.3 micrograms/ml at 9 h to 1.0 +/- 1.0 micrograms/ml at 64 h in the chronic pain patients. The incidence of side effects was approximately the same in both groups. No signs of accumulation or toxic reactions to bupivacaine were seen. |
| | |
Authors:
|
P P Raj; D Knarr; E Vigdorth; R V Gregg; D D Denson; H H Edström |
Related Documents
:
|
22253576 - The inadequate treatment of pain: collateral damage from the war on drugs. 18182416 - Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine... 1782716 - An evaluation of post-operative packing in nasal septal surgery. 21824586 - Cervical facet-mediated pain. 15171526 - Soap induced urethral pain in boys. 18082786 - Ed endovaginal pelvic ultrasound in nonpregnant women with right lower quadrant pain. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Pain Volume: 34 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 1988 Jul |
Date Detail:
|
Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7508686 Medline TA: Pain Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
|
Department of Anesthesia, University of Cincinnati College of Medicine, OH. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Analgesia* Anesthesia, Epidural* Back Pain / therapy* Bupivacaine* Female Humans Male Nerve Block Pain, Postoperative / therapy* |
| Chemical | |
Reg. No./Substance:
|
2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Therapeutic possibilities for the handicapped child
Next Document: Neuromuscular thermography in orthopaedic surgery. A usage poll.