Document Detail

Difference between serum beta-human chorionic gonadotropin levels in pregnancies after in vitro maturation and in vitro fertilization treatments.
MedLine Citation:
PMID:  20579986     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To compare β-hCG levels measured as the first pregnancy test in women who conceived after in vitro maturation (IVM) or IVF.
DESIGN: Retrospective matched cohort analysis.
SETTING: University-based medical center.
PATIENT(S): Women treated with IVM or IVF.
INTERVENTION(S): We studied the first serum β-hCG levels in 104 pregnant women who were successfully treated with IVM and in another 104 women with IVF treatment. Blood samplings for β-hCG were drawn on day 12-15 after ET. The two groups were matched by age, order of pregnancy, and day of blood sampling.
MAIN OUTCOME MEASURE(S): First β-hCG levels.
RESULT(S): Serum β-hCG levels on days 12 to 13 after ET of IVM viable singleton pregnancies were significantly higher than those of IVF pregnancies (343.2±48.4 vs. 264.0±29.2 IU/L, 95% confidence interval [CI] 22-229). Similarly, β-hCG levels on days 14 to 15 after ET of IVM viable singleton pregnancies were higher than those of IVF pregnancies (350.1±126.4 vs. 284.4±30.2 IU/L). Similar trends were found in β-hCG levels on days 12 to 13 after ET of twin viable pregnancies (IVM, 682.1±97.7 vs. IVF, 434.5±41.8 IU/L; 95% CI 44-662). Grouped linear regression with covariance analysis showed a significant difference between IVM and IVF regression lines.
CONCLUSION(S): The first serum β-hCG levels in pregnancies after IVM are consistently higher than those after IVF treatment. More studies are needed to elucidate these findings.
Benny Almog; Jana Al-Shalaty; Boaz Sheizaf; Fady Shehata; Weon-Young Son; Seang Lin Tan; Togas Tulandi
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Publication Detail:
Type:  Journal Article     Date:  2010-06-26
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
McGill Reproductive Center, Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
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