Document Detail

Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome.
MedLine Citation:
PMID:  2891886     Owner:  NLM     Status:  MEDLINE    
24 infants consecutively treated with acyclovir or vidarabine for neonatal herpes simplex virus (HSV) encephalitis were followed up for 6 months to 3 years to assess neurological and developmental outcome. 15 patients had HSV-2 and 9 had HSV-1 encephalitis. Infants with HSV-2 encephalitis presented with a higher frequency of seizures, greater pleocytosis and protein concentrations in the cerebrospinal fluid, and more frequent evidence of structural damage on computerised tomographic scans of the brain than did those with HSV-1 encephalitis. 1 patient died. All 9 HSV-1 patients were normal at follow-up (mean 19.4 months) compared with only 4 (23%) of the 14 surviving HSV-2 infected infants (p = 0.003). Among infants with HSV-2 encephalitis, 50% became microcephalic; 57% had seizure disorders; 64% had ophthalmological defects; 64% had cerebral palsy; and 57% had mental retardation. Infants with neonatal HSV-1 encephalitis treated with systemic antiviral chemotherapy have excellent neurological outcomes; the neurological morbidity of those with HSV-2 encephalitis is still high.
L Corey; R J Whitley; E F Stone; K Mohan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:    1988 Jan 2-9
Date Detail:
Created Date:  1988-02-05     Completed Date:  1988-02-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  AIM; IM    
Department of Laboratory Medicine, University of Washington, Seattle.
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MeSH Terms
Acyclovir / therapeutic use
Brain / physiopathology
Central Nervous System Diseases / cerebrospinal fluid,  etiology*,  radiography
Follow-Up Studies
Herpes Simplex / complications*,  drug therapy,  physiopathology,  radiography
Infant, Newborn
Vidarabine / therapeutic use
Grant Support
Reg. No./Substance:
5536-17-4/Vidarabine; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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