| Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. | |
MedLine Citation:
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PMID: 16956974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller. |
Authors:
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Lev A Zhivotovsky; Peter A Underhill; Marcus W Feldman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-09-06 |
Journal Detail:
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Title: Molecular biology and evolution Volume: 23 ISSN: 0737-4038 ISO Abbreviation: Mol. Biol. Evol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-03 Completed Date: 2007-03-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8501455 Medline TA: Mol Biol Evol Country: United States |
Other Details:
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Languages: eng Pagination: 2268-70 Citation Subset: IM |
Affiliation:
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N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. levazh@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chromosomes, Human, Y
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genetics Evolution, Molecular* Genetic Variation Genetics, Population Germ-Line Mutation / physiology* Haplotypes* Humans Male Microsatellite Repeats / physiology Mutation / physiology* Stochastic Processes* |
| Grant Support | |
ID/Acronym/Agency:
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GM 28016/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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