Document Detail


Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size.
MedLine Citation:
PMID:  16956974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller.
Authors:
Lev A Zhivotovsky; Peter A Underhill; Marcus W Feldman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-09-06
Journal Detail:
Title:  Molecular biology and evolution     Volume:  23     ISSN:  0737-4038     ISO Abbreviation:  Mol. Biol. Evol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-03-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8501455     Medline TA:  Mol Biol Evol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2268-70     Citation Subset:  IM    
Affiliation:
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. levazh@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Chromosomes, Human, Y / genetics
Evolution, Molecular*
Genetic Variation
Genetics, Population
Germ-Line Mutation / physiology*
Haplotypes*
Humans
Male
Microsatellite Repeats / physiology
Mutation / physiology*
Stochastic Processes*
Grant Support
ID/Acronym/Agency:
GM 28016/GM/NIGMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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