| Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. | |
MedLine Citation:
|
PMID: 16956974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Within a Y-chromosome haplogroup defined by unique event mutations, variation in microsatellites can accumulate due to their rapid mutation. Estimates based on pedigrees for the Y-chromosome microsatellite mutation rate are 3 or more times greater than the same estimates from evolutionary considerations. We show by simulation that the haplogroups that survive the stochastic processes of drift and extinction accumulate microsatellite variation at a lower rate than predicted from corresponding pedigree estimates; in particular, under constant total population size, the accumulated variance is on average 3-4 times smaller. |
Authors:
|
Lev A Zhivotovsky; Peter A Underhill; Marcus W Feldman |
Related Documents
:
|
19822734 - X-linked variation in immune response in drosophila melanogaster. 25253574 - Detecting associated single-nucleotide polymorphisms on the x chromosome in case contro... 3416654 - Does heterochromatin variation potentiate speciation? a study in nesokia. 18510454 - Protective role of dc-sign (cd209) neck-region alleles with <5 repeat units in hiv-1 tr... 25215184 - Evaluating the y chromosomal timescale in human demographic and lineage dating. 2338344 - Partial trisomy of the distal segment 14q. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-09-06 |
Journal Detail:
|
Title: Molecular biology and evolution Volume: 23 ISSN: 0737-4038 ISO Abbreviation: Mol. Biol. Evol. Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-11-03 Completed Date: 2007-03-15 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8501455 Medline TA: Mol Biol Evol Country: United States |
Other Details:
|
Languages: eng Pagination: 2268-70 Citation Subset: IM |
Affiliation:
|
N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. levazh@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromosomes, Human, Y
/
genetics Evolution, Molecular* Genetic Variation Genetics, Population Germ-Line Mutation / physiology* Haplotypes* Humans Male Microsatellite Repeats / physiology Mutation / physiology* Stochastic Processes* |
| Grant Support | |
ID/Acronym/Agency:
|
GM 28016/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Robustness of coalescent estimators to between-lineage mutation rate variation.
Next Document: Feature-selective attention enhances color signals in early visual areas of the human brain.