| Diets with high or low protein content and glycemic index for weight-loss maintenance. | |
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MedLine Citation:
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PMID: 21105792 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power. METHODS: We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, in a two-by-two factorial design, to one of five ad libitum diets to prevent weight regain over a 26-week period: a low-protein and low-glycemic-index diet, a low-protein and high-glycemic-index diet, a high-protein and low-glycemic-index diet, a high-protein and high-glycemic-index diet, or a control diet. RESULTS: A total of 1209 adults were screened (mean age, 41 years; body-mass index [the weight in kilograms divided by the square of the height in meters], 34), of whom 938 entered the low-calorie-diet phase of the study. A total of 773 participants who completed that phase were randomly assigned to one of the five maintenance diets; 548 completed the intervention (71%). Fewer participants in the high-protein and the low-glycemic-index groups than in the low-protein-high-glycemic-index group dropped out of the study (26.4% and 25.6%, respectively, vs. 37.4%; P=0.02 and P=0.01 for the respective comparisons). The mean initial weight loss with the low-calorie diet was 11.0 kg. In the analysis of participants who completed the study, only the low-protein-high-glycemic-index diet was associated with subsequent significant weight regain (1.67 kg; 95% confidence interval [CI], 0.48 to 2.87). In an intention-to-treat analysis, the weight regain was 0.93 kg less (95% CI, 0.31 to 1.55) in the groups assigned to a high-protein diet than in those assigned to a low-protein diet (P=0.003) and 0.95 kg less (95% CI, 0.33 to 1.57) in the groups assigned to a low-glycemic-index diet than in those assigned to a high-glycemic-index diet (P=0.003). The analysis involving participants who completed the intervention produced similar results. The groups did not differ significantly with respect to diet-related adverse events. CONCLUSIONS: In this large European study, a modest increase in protein content and a modest reduction in the glycemic index led to an improvement in study completion and maintenance of weight loss. (Funded by the European Commission; ClinicalTrials.gov number, NCT00390637.). |
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Authors:
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Thomas Meinert Larsen; Stine-Mathilde Dalskov; Marleen van Baak; Susan A Jebb; Angeliki Papadaki; Andreas F H Pfeiffer; J Alfredo Martinez; Teodora Handjieva-Darlenska; Marie Kunešová; Mats Pihlsgård; Steen Stender; Claus Holst; Wim H M Saris; Arne Astrup; |
Publication Detail:
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Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The New England journal of medicine Volume: 363 ISSN: 1533-4406 ISO Abbreviation: N. Engl. J. Med. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-25 Completed Date: 2010-12-02 Revised Date: 2011-09-06 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: United States |
Other Details:
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Languages: eng Pagination: 2102-13 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark. tml@life.ku.dk |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00390637 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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etiology Adult Biological Markers / urine Body Mass Index Diet, Carbohydrate-Restricted Diet, Protein-Restricted* / adverse effects Diet, Reducing* Dietary Proteins / administration & dosage* Glycemic Index* Humans Intention to Treat Analysis Obesity / diet therapy Overweight / diet therapy* Patient Compliance Weight Loss |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Dietary Proteins |
| Comments/Corrections | |
Comment In:
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N Engl J Med. 2010 Nov 25;363(22):2159-61
[PMID:
21105799
]
N Engl J Med. 2011 Feb 24;364(8):779-80; author reply 780-1 [PMID: 21345116 ] N Engl J Med. 2011 Feb 24;364(8):779; author reply 780-1 [PMID: 21345117 ] N Engl J Med. 2011 Feb 24;364(8):780; author reply 780-1 [PMID: 21345115 ] Evid Based Med. 2011 Aug;16(4):112-3 [PMID: 21386115 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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