| Diets rich in fruits and vegetables suppress blood biomarkers of metabolic stress in overweight women. | |
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MedLine Citation:
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PMID: 22226662 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: This study was performed to evaluate the effects of high vegetable-fruit (high-VF) and low vegetable-fruit (low-VF) diet on surrogate biomarkers of adiposity-related metabolic disturbances. METHODS: Overweight women (n=22, 19-29years) participated in the study between July and August, 2007 in Seoul, Korea. It consisted of either high-VF diet (12 servings of VF/day) or low-VF diet (2 servings of VF/day). Plasma concentration of carotenoids and biomarkers of inflammation and oxidative stress were determined before and after each intervention period. RESULTS: Study results indicated that body fat content is positively correlated with plasma interleukin (IL)-6, C-reactive protein (CRP), and leptin concentrations at baseline. Oxidative DNA damage and lipopolysaccharide (LPS)-activated production of IL-1β and IL-6 in peripheral blood mononuclear cells (PBMCs) were decreased with high-VF diet while low-VF diet increased those markers. Changes in the concentration of plasma total carotenoid and β-carotene were inversely correlated with change in plasma IL-1β concentration. Differences in IL-β production in LPS-activated PBMCs were inversely correlated with changes in plasma concentration of lutein-zeaxanthin. Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs. CONCLUSION: Daily intake of vegetables and fruits can modify adiposity-related metabolic disturbances. |
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Authors:
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Jee-Young Yeon; Hyun-Sook Kim; Mi-Kyung Sung |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
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Title: Preventive medicine Volume: - ISSN: 1096-0260 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0322116 Medline TA: Prev Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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