Document Detail

Diets high in polyunsaturated oils decrease lymphocyte membrane anisotropy and B-cell mitogenesis.
MedLine Citation:
PMID:  8719135     Owner:  NLM     Status:  MEDLINE    
Balb/c mice were fed semipurified diets containing 40% of total calories as lipids: olive, safflower, or fish oil. After 2 weeks of feeding, splenic mononuclear cells were isolated and assayed for steady-state fluorescence anisotropy by means of the probe diphenylhexatriene. Splenocytes were also incubated with the mitogens concanavalin A, phytohemagglutinin, or lipopolysaccharide; subsequent uptake of tritiated thymidine was measured as an index of proliferation. No differences were observed in the membrane anisotropy and mitogenesis of mice fed the olive oil diet (high in monounsaturated fatty acids) and the control group. However, membrane anisotropy was significantly lowered in mice fed the safflower or fish oil diets (high in polyunsaturated fatty acids), and the mitogenic response to lipopolysaccharide was suppressed. Mitogenic responses to concanavalin A and phytohemagglutinin were not significantly affected by the type of lipid in the diet.
M D Peck; Z Li; T Han; B C Pressman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  11     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-7     Citation Subset:  IM    
Department of Surgery, University of Miami School of Medicine, Florida, USA.
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MeSH Terms
B-Lymphocytes / drug effects,  immunology
Dietary Fats, Unsaturated / administration & dosage*
Fatty Acids, Unsaturated / administration & dosage
Lymphocyte Activation / drug effects
Lymphocytes / drug effects*,  metabolism*
Membrane Fluidity / drug effects*
Mice, Inbred BALB C
Spleen / cytology,  drug effects
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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