Document Detail

Diets high in polyunsaturated oils decrease lymphocyte membrane anisotropy and B-cell mitogenesis.
MedLine Citation:
PMID:  8719135     Owner:  NLM     Status:  MEDLINE    
Balb/c mice were fed semipurified diets containing 40% of total calories as lipids: olive, safflower, or fish oil. After 2 weeks of feeding, splenic mononuclear cells were isolated and assayed for steady-state fluorescence anisotropy by means of the probe diphenylhexatriene. Splenocytes were also incubated with the mitogens concanavalin A, phytohemagglutinin, or lipopolysaccharide; subsequent uptake of tritiated thymidine was measured as an index of proliferation. No differences were observed in the membrane anisotropy and mitogenesis of mice fed the olive oil diet (high in monounsaturated fatty acids) and the control group. However, membrane anisotropy was significantly lowered in mice fed the safflower or fish oil diets (high in polyunsaturated fatty acids), and the mitogenic response to lipopolysaccharide was suppressed. Mitogenic responses to concanavalin A and phytohemagglutinin were not significantly affected by the type of lipid in the diet.
M D Peck; Z Li; T Han; B C Pressman
Related Documents :
15621515 - Influence of mitochondrial membrane fatty acid composition on proton leak and h2o2 prod...
15092975 - An experimental soft-release of oil-spill rehabilitated american coots (fulica american...
8570865 - Protective effect of coconut oil on renal necrosis occurring in rats fed a methyl-defic...
1923905 - The effect of the level of dietary corn oil on mouse skin carcinogenesis.
1752825 - Toxicity and tissue accumulation of copper in chicks fed casein and soy-based diets.
12831945 - Body composition interpretation. contributions of the fat-free mass index and the body ...
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  11     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:    1995 Nov-Dec
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-7     Citation Subset:  IM    
Department of Surgery, University of Miami School of Medicine, Florida, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
B-Lymphocytes / drug effects,  immunology
Dietary Fats, Unsaturated / administration & dosage*
Fatty Acids, Unsaturated / administration & dosage
Lymphocyte Activation / drug effects
Lymphocytes / drug effects*,  metabolism*
Membrane Fluidity / drug effects*
Mice, Inbred BALB C
Spleen / cytology,  drug effects
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of small intestinal motility by casein: a role of beta casomorphins?
Next Document:  Diabetic renal disease: microalbuminuria, implications and intervention.