Document Detail

Diets high in corn oil or extra-virgin olive oil provided from weaning advance sexual maturation and differentially modify susceptibility to mammary carcinogenesis in female rats.
MedLine Citation:
PMID:  21391126     Owner:  NLM     Status:  MEDLINE    
Based on the importance of early-life events in breast cancer risk, we have investigated the effects of high-fat diets on maturation, mammary gland development, and its susceptibility to transformation. Female Sprague-Dawley rats were fed a lowfat (LF), high corn oil (HCO), or high extra-virgin olive oil (HOO) diet from weaning and gavaged with 7,12-dimethylbenz[a]anthracene. Body weight and mass increased in the HCO group compared to the LF group. The vaginal opening was advanced in both high-fat groups, especially in the HCO group. This HCO group also had increased body weight around puberty, more corpora lutea at post-puberty, and tended to have higher kisspeptin levels in the hypothalamus. Both high-fat diets induced subtle modifications in the morphology of the mammary gland, with no changes on β-casein or hormone receptors expression in the gland. The HCO diet had a clearly stimulating effect of carcinogenesis, inducing the earliest appearance of tumors and the highest tumor incidence and yield, whereas the HOO diet seemed to have a weak enhancing effect, increasing tumor yield. Our data suggest a strong influence of the HCO diet in sexual maturation and mammary cancer risk, while rats fed the HOO diet were more similar to the controls.
Raquel Moral; Raquel Escrich; Montserrat Solanas; Elena Vela; Irmgard Costa; M Carme Ruiz de Villa; Eduard Escrich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nutrition and cancer     Volume:  63     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2011  
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-08-15     Revised Date:  2011-09-02    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  410-20     Citation Subset:  IM    
Department of Cell Biology, Physiology and Immunology, Physiology Unit, Medicine School, Universitat Autònoma de Barcelona, Barcelona, Spain.
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MeSH Terms
9,10-Dimethyl-1,2-benzanthracene / toxicity
Amino Acid Sequence
Analysis of Variance
Body Weight
Breast / growth & development,  pathology*
Caseins / analysis,  genetics
Cell Transformation, Neoplastic / pathology
Corn Oil / administration & dosage*
Dietary Fats / administration & dosage*
Estrogen Receptor alpha / genetics
Gene Expression Regulation, Neoplastic
Mammary Neoplasms, Experimental / metabolism,  pathology
Molecular Sequence Data
Ovary / growth & development,  pathology
Plant Oils / administration & dosage*
Proteins / genetics,  metabolism
RNA, Messenger / genetics,  metabolism
Rats, Sprague-Dawley
Sexual Maturation*
Reg. No./Substance:
0/Caseins; 0/Dietary Fats; 0/Estrogen Receptor alpha; 0/Kiss1 protein, rat; 0/Plant Oils; 0/Proteins; 0/RNA, Messenger; 57-97-6/9,10-Dimethyl-1,2-benzanthracene; 8001-25-0/olive oil; 8001-30-7/Corn Oil

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