| Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. | |
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MedLine Citation:
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PMID: 21795022 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Animal studies have demonstrated that dietary supplementation with flaxseed oil inhibits colorectal cancer growth. Recent data indicate that walnuts have strong antiproliferative properties against colon cancer cells in vitro but no previous study has assessed the effects of walnuts in vivo or performed a joint evaluation of flaxseed oil and walnuts. The aim of the present study was to examine the effect of dietary walnuts on colorectal cancer in vivo and to comparatively evaluate their efficacy in relation to flaxseed oil. METHODS: HT-29 human colon cancer cells were injected in 6-wk-old female nude mice. After a 1-wk acclimation period, mice (n = 48) were randomized to diets containing ∼19% of total energy from walnuts, flaxseed oil, or corn oil (control) and were subsequently studied for 25 d. RESULTS: Tumor growth rate was significantly slower in walnut-fed and flaxseed-fed mice compared with corn oil-fed animals (P < 0.05) by 27% and 43%, respectively. Accordingly, final tumor weight was reduced by 33% and 44%, respectively (P < 0.05 versus control); the differences between walnut and flaxseed diets did not reach significance. We found no differences among groups in metabolic and hormonal profile, serum antioxidant capacity, or inflammation (P > 0.05). However, walnuts and flaxseed oil significantly reduced serum expression levels of angiogenesis factors, including vascular endothelial growth factor (by 30% and 80%, respectively), and approximately doubled total necrotic areas despite smaller tumor sizes (P < 0.05 versus control). Dietary walnuts significantly decreased angiogenesis (CD34 staining; P = 0.017 versus control), whereas this effect did not reach significance in the flaxseed oil group (P = 0.454 versus control). CONCLUSION: We conclude that walnuts in the diet inhibit colorectal cancer growth by suppressing angiogenesis. Further studies are needed to confirm our findings in humans and explore underlying mechanisms. |
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Authors:
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Jutta M Nagel; Mary Brinkoetter; Faidon Magkos; Xiaowen Liu; John P Chamberland; Sunali Shah; Jinrong Zhou; George Blackburn; Christos S Mantzoros |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-07-27 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 28 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-14 Completed Date: 2012-04-16 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 67-75 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inhibitors
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therapeutic use* Animals Antigens, CD34 / metabolism Antineoplastic Agents, Phytogenic / therapeutic use* Colorectal Neoplasms / blood, diet therapy*, metabolism, pathology Dietary Supplements Female HT29 Cells Humans Juglans* Linseed Oil / therapeutic use Mice Mice, Nude Necrosis Neovascularization, Pathologic / prevention & control* Nuts* Random Allocation Tumor Burden Vascular Endothelial Growth Factors / blood Xenograft Model Antitumor Assays |
| Grant Support | |
ID/Acronym/Agency:
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DK081913/DK/NIDDK NIH HHS; P30 DK040561-15/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inhibitors; 0/Antigens, CD34; 0/Antineoplastic Agents, Phytogenic; 0/Vascular Endothelial Growth Factors; 8001-26-1/Linseed Oil |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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