Document Detail

Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?
MedLine Citation:
PMID:  20384848     Owner:  NLM     Status:  MEDLINE    
Numerous risk factors for instability of oral anticoagulation have been identified, including variability in vitamin K intake. However, few studies have directly tested the feasibility of manipulating dietary vitamin K to achieve stable oral anticoagulation. Recent findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy. The approach appears to be effective for those patients who are under-anticoagulated and consume a small number of vitamin K-rich food sources. While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required.
Sarah L Booth
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  68     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-81     Citation Subset:  IM    
Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachussetts 02111, USA.
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MeSH Terms
Anticoagulants / administration & dosage,  therapeutic use*
Blood Coagulation Disorders / blood,  drug therapy*
Drug Stability
Randomized Controlled Trials as Topic
Vitamin K / administration & dosage,  therapeutic use*
Warfarin / therapeutic use
Reg. No./Substance:
0/Anticoagulants; 12001-79-5/Vitamin K; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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