Document Detail

Dietary vitamin E supplementation lowers blood pressure in spontaneously hypertensive rats.
MedLine Citation:
PMID:  12349898     Owner:  NLM     Status:  MEDLINE    
In spontaneously hypertensive rats (SHRs) excess endogenous aldehydes bind sulfhydryl groups of membrane proteins, altering membrane Ca2+ channels and increasing cytosolic free calcium and blood pressure. The thiol compound, N-acetyl cysteine, normalizes elevated blood pressure in SHRs by binding excess endogenous aldehydes. Vitamin E increases tissue glutathione levels--a storage form of cysteine. The aim of the present study was to investigate whether a dietary supplementation of vitamin E lowers blood pressure and prevents renal vascular changes by normalizing tissue aldehyde conjugates and cytosolic [Ca2+] in SHRs. Starting at 12 weeks of age, animals were divided into three groups of six animals each. Animals in the WKY-control group and SHR-control group were given a normal diet and the SHR-vitamin E group a diet supplemented with vitamin E (34 mg/ kg feed) for the next 9 weeks. After 9 weeks, systolic blood pressure, platelet [Ca2+]i, and liver, kidney and aortic aldehyde conjugates were significantly higher in SHR controls as compared to WKY controls and the SHR-vitamin E group. SHR-controls also showed smooth muscle cell hyperplasia in the small arteries and arterioles of the kidney. Dietary vitamin E supplementation in SHRs lowered the systolic blood pressure, cytosolic [Ca2+], tissue aldehyde conjugates and attenuated adverse renal vascular changes.
S Vasdev; V Gill; S Parai; L Longerich; V Gadag
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  238     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2003-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  111-7     Citation Subset:  IM    
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St John's, Canada.
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MeSH Terms
Administration, Oral
Aldehydes / analysis
Antihypertensive Agents / pharmacology,  therapeutic use
Blood Platelets / drug effects,  metabolism
Blood Pressure / drug effects*
Body Weight / drug effects
Calcium / blood
Dietary Supplements
Drinking Behavior / drug effects
Eating / drug effects
Hypertension / drug therapy
Organ Size / drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Time Factors
Vitamin E / administration & dosage,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Aldehydes; 0/Antihypertensive Agents; 1406-18-4/Vitamin E; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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