Document Detail

Dietary vitamin E decreases ESR signal intensity in hepatic microsomal preparations from malignant hyperthermia susceptible pigs.
MedLine Citation:
PMID:  1648019     Owner:  NLM     Status:  MEDLINE    
On incubation with the spin trap alpha-(4-pyridyl-l-oxide)-N-tert-butylnitrone (4-POBN), a characteristic electron spin resonance (ESR) signal was produced at a greater rate in hepatic microsomal fractions from malignant hyprthermia susceptible (MHS) pigs compared with resistant (MHR) pigs. This was accompanied by increased formation of thiobarbituric acid reactive substances (TBARS). Supplementation of diets for six weeks with 235 mg alpha-tocopherol acetate/kg significantly increased microsomal vitamin E content of both pigs types. Moreover, the rate of formation of TBARS and ESR signal height of incubated microsomes from supplemented MHS pigs was decreased to that of MHR pigs. Elevated pyruvate kinase activities and TBARS concentrations in plasma of MHS pigs were also moderated by dietary vitamin E. Vitamin E supplementation may decrease the peroxidative events associated with MH.
G G Duthie; D B McPhail; P C Morrice; J R Arthur
Related Documents :
10674169 - The course of phosphorus excretion in growing pigs fed continuously increasing phosphor...
1142729 - Selected blood values for macaca nemestrina fed semipurified fiber-free liquid diets.
11204719 - Influence of a high ambient temperature on lipid metabolism in the growing pig.
12643489 - Growth performance, carcass and pork quality of finisher pigs fed oat-based diets conta...
641599 - Blood and liver folacin activity, formiminoglutamic acid excretion, growth and hematolo...
21951309 - Anti-obesity efficacy of lh-21, a cannabinoid cb(1) receptor antagonist with poor brain...
14742899 - Maternal selenium deficiency increases hydrogen peroxide and total lipid peroxides in p...
10592849 - Effects of various levels of dietary lepidium sativum l. seeds in rats.
8027859 - L-canavanine influences feed intake, plasma basic amino acid concentrations and kidney ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical research communications     Volume:  14     ISSN:  8755-0199     ISO Abbreviation:  Free Radic. Res. Commun.     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-02     Completed Date:  1991-08-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8709453     Medline TA:  Free Radic Res Commun     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Rowett Research Institute, Bucksburn, Aberdeen, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Electron Spin Resonance Spectroscopy
Free Radicals
Malignant Hyperthermia / drug therapy*,  metabolism
Microsomes, Liver / drug effects*,  metabolism
Nitrogen Oxides
Spin Labels
Vitamin E / pharmacology*
Reg. No./Substance:
0/Free Radicals; 0/Nitrogen Oxides; 0/Pyridines; 0/Spin Labels; 0/alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The autoxidation of iron(II) in aqueous systems: the effects of iron chelation by physiological, non...
Next Document:  Difficulties encountered in the detection of nitric oxide (NO) by spin trapping techniques. A cautio...