Document Detail


Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats.
MedLine Citation:
PMID:  10569195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spontaneously hypertensive rats (SHRs) excess endogenous aldehydes bind sulfhydryl groups of membrane proteins, altering membrane Ca2+ channels, increasing cytosolic free calcium and blood pressure. N-acetyl cysteine normalizes elevated blood pressure in SHRs by binding excess endogenous aldehydes. It is known that dietary vitamin B6 supplementation can increase the level of endogenous cysteine. Our objective was to investigate whether a dietary supplementation of vitamin B6 can prevent hypertension and associated changes in SHRs. Starting at 7 weeks of age, animals were divided into three groups of six animals each. Animals in WKY-control group and SHR-control group were given a normal vitamin B6 diet; and SHR-vitamin B6 group, a high vitamin B6 diet (20 times the recommended dietary intake; RDA) for the next 14 weeks. After 14 weeks, systolic blood pressure, platelet [Ca2+]i and liver, kidney and aortic aldehyde conjugates were significantly higher in SHR controls compared to WKY controls. These animals also showed smooth muscle cell hyperplasia in the small arteries and arterioles of the kidneys. Dietary vitamin B6 supplementation attenuated the increase in systolic blood pressure, tissue aldehyde conjugates and associated changes. These results further support the hypothesis that aldehydes are involved in increased systolic blood pressure in SHRs and suggest that vitamin B6 supplementation may be an effective antihypertensive.
Authors:
S Vasdev; C A Ford; S Parai; L Longerich; V Gadag
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  200     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-12-22     Completed Date:  1999-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Affiliation:
Department of Medicine, Health Sciences Centre, Memorial University of Newfoundland, St. John's, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aldehydes / metabolism
Animals
Antihypertensive Agents / administration & dosage*
Aorta / drug effects,  metabolism
Blood Platelets / metabolism
Blood Pressure / drug effects
Calcium / blood
Hypertension / drug therapy*,  pathology,  physiopathology
Kidney / drug effects,  metabolism,  pathology
Liver / drug effects,  metabolism
Organ Size / drug effects
Pyridoxine / administration & dosage*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Antihypertensive Agents; 65-23-6/Pyridoxine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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