| Dietary uptake kinetics of 2,2',5,5'-tetrachlorobiphenyl in rainbow trout. | |
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MedLine Citation:
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PMID: 11408368 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The disposition of [UL-(14)C]2,2',5,5'-tetrachlorobiphenyl (TCB) in rainbow trout (Oncorhynchus mykiss) was studied in acute dietary exposures using TCB-contaminated fathead minnows (Pimephales promelas). Trout were sampled at several postfeeding time points and TCB-derived radioactivity was measured in gut contents and selected tissues. Gastric evacuation was exponential with time and was 95% complete within 36 h of feeding. The ratio of activity in upper intestinal tissue to that in blood declined between 6 and 48 h, as did the lumenal contents/tissue ratio. Stomach content lipid declined between 0 and 24 h, while the lipid content of chyme remained relatively constant. These observations are consistent with liquid phase emptying of lipid and TCB to the upper intestine followed by rapid coassimilation. Tissue/blood activity ratios for the stomach, lower intestine, muscle, liver, and kidney were constant and probably represented near equilibrium conditions. The fat/blood activity ratio increased through 96 h, indicating that TCB was redistributing to fat. The lower intestinal tissue/feces activity ratio increased between 6 and 24 h and then declined rapidly. Fecal lipid content also increased between 6 and 24 h, but the amount of this increase was insufficient to explain observed changes in the distribution of TCB-derived activity. A small amount of 3-hydroxy TCB was detected in feces. Generally, however, metabolism had little or no impact on the uptake, distribution or elimination of TCB. Measured assimilation efficiencies exceeded 90% and are the highest ever reported in fish feeding studies with TCB. |
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Authors:
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J W Nichols; P N Fitzsimmons; F W Whiteman; D W Kuehl; B C Butterworth; C T Jenson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug metabolism and disposition: the biological fate of chemicals Volume: 29 ISSN: 0090-9556 ISO Abbreviation: Drug Metab. Dispos. Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-06-15 Completed Date: 2001-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9421550 Medline TA: Drug Metab Dispos Country: United States |
Other Details:
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Languages: eng Pagination: 1013-22 Citation Subset: IM |
Affiliation:
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U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, Duluth, Minnesota 55804, USA. nichols.john@epa.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cyprinidae Diet* Dietary Fats / metabolism Dose-Response Relationship, Drug Gas Chromatography-Mass Spectrometry Kinetics Oncorhynchus mykiss Polychlorinated Biphenyls / pharmacokinetics* Spectrometry, Mass, Electrospray Ionization Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Polychlorinated Biphenyls; 35693-99-3/2,5,2',5'-tetrachlorobiphenyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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