Document Detail

Dietary unsaturated fatty acids increase plasma glucagon-like peptide-1 and cholecystokinin and may decrease premeal ghrelin in lactating dairy cows.
MedLine Citation:
PMID:  18349237     Owner:  NLM     Status:  MEDLINE    
Previous reports have indicated that dietary unsaturated fat can decrease energy intake of lactating dairy cattle. However, the mechanism for this response is unclear. To evaluate the potential role of gut peptides, periprandial concentrations of cholecystokinin (CCK), glucagon-like peptide 1 (GLP-1), and ghrelin were measured. From a replicated 4 x 4 Latin square experiment, 4 cows from a single square were selected for analysis of responses to 3 treatments: a control diet (5.5% total fatty acids, 65% unsaturated), a diet with added saturated fat (SAT, 8.3% fatty acids, 47% unsaturated), and a diet with added unsaturated fat (UNS, 7.8% fatty acids, 63% unsaturated). The SAT treatment increased duodenal flow of saturated fatty acids compared with UNS and control and, despite the fact that ruminal biohydrogenation altered fatty acid profiles of digesta, UNS increased duodenal flow of unsaturated fatty acids compared with SAT and control. Blood samples were collected at 8-min intervals through the first 2 meals of the day and analyzed by commercial radioimmunoassays. The UNS treatment increased plasma CCK concentration relative to SAT and control, and increased plasma GLP-1 concentration compared with control. Furthermore, fat treatments tended to suppress the prandial ghrelin surge that was evident for control. Suppression of feed intake by unsaturated fats is likely mediated in part by increased secretion of CCK and GLP-1, and dietary fat may also inhibit ghrelin release before conditioned meals.
B J Bradford; K J Harvatine; M S Allen
Related Documents :
11522057 - Diagnostic patterns of very-long-chain fatty acids in plasma of patients with x-linked ...
8181467 - Biosynthesis of gangliosides containing c18:1 and c20:1 [3-14c]sphingosine after admini...
6293567 - Inhibition of gastric (h+ + k+)-atpase by unsaturated long-chain fatty acids.
18036137 - The gup1 homologue of trypanosoma brucei is a gpi glycosylphosphatidylinositol remodelase.
10579427 - Chemoattraction of ichthyophthirius multifiliis (ciliophora) theronts to host molecules.
111307 - Influence of angiotensins (i, ii, & iii), bradykinin and arachidonic acid on renomedull...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of dairy science     Volume:  91     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-19     Completed Date:  2008-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1443-50     Citation Subset:  IM    
Department of Animal Science, Michigan State University, East Lansing 48824, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Animal Feed / analysis
Cholecystokinin / blood*
Dietary Fats, Unsaturated / administration & dosage*
Dietary Supplements*
Duodenum / metabolism
Eating / drug effects
Fatty Acids / administration & dosage
Feeding Behavior / drug effects
Ghrelin / blood*
Glucagon-Like Peptide 1 / blood*
Time Factors
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Ghrelin; 89750-14-1/Glucagon-Like Peptide 1; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of manual versus semiautomatic milk recording systems in dairy goats.
Next Document:  The effect of silage cutting height on the nutritive value of a normal corn silage hybrid compared w...