Document Detail

Dietary tryptophan depletion according to body weight - a new treatment option in acute mania?
MedLine Citation:
PMID:  18849122     Owner:  NLM     Status:  MEDLINE    
Decreased neurotransmission of serotonin (5-HT) was shown to be related to the development of depressive symptoms, whereas recent preliminary evidence suggests that acute mania may be related to a hyperserotonergic state. The reduction of central nervous 5-HT synthesis achieved by a new modification of the dietary rapid tryptophan depletion technique, with the relevant amino acids dosed according to body weight, is hypothesized by the authors to be a further option of treatment during acute mania, in particular in view of a decrease in adverse reactions, a reduced amount of amino acids needed for sufficient depletion, but also improved tolerability. However, ethical issues may limit such studies investigating this relationship in acutely manic patients, in particular in view of informed consent.
Florian Daniel Zepf; Lars Wöckel; Fritz Poustka; Martin Holtmann
Publication Detail:
Type:  Journal Article     Date:  2008-10-11
Journal Detail:
Title:  Medical hypotheses     Volume:  72     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  47-8     Citation Subset:  IM    
Department of Child and Adolescent Psychiatry and Psychotherapy, Goethe University of Frankfurt/Main, Deutschordenstr. 50/Building 92, 60528 Frankfurt am Main, Germany.
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MeSH Terms
Antimanic Agents
Bipolar Disorder / diet therapy*
Body Weight*
Food Habits*
Tryptophan / deficiency*
Reg. No./Substance:
0/Antimanic Agents; 73-22-3/Tryptophan

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