Document Detail

Dietary trans fatty acids and composition of human atheromatous plaques.
MedLine Citation:
PMID:  15309454     Owner:  NLM     Status:  MEDLINE    
Dietary fatty acids are incorporated into atheromatous plaques mainly in the form of cholesterol esters. Physicochemical properties of the plaque (e. g. mechanical strength) depend on its fatty acid composition. Trans isomers of unsaturated fatty acids (TFA) are known to reduce the availability of fatty acid precursors for the synthesis of anticoagulant PG(1) and PG(3) prostaglandins. The present study was undertaken to determine the content of trans isomers in atheromatous plaques and to search for correlations between trans isomers in the plaque and adipose tissue. Atheromatous plaques were obtained from 31 patients who underwent surgery due to atherosclerotic stenosis of the abdominal aorta, iliac or femoral arteries. Fatty acids were extracted and separated as methyl esters using gas chromatography (GC) with an internal standard. Correlations were searched for with statistical methods, taking the level of significance as p < 0.05. We found spatial and positional isomers of sixteen- and eighteen-carbon fatty acids in plaques and adipose tissue, with elaidic acid (C18:1 trans-9) being the most abundant. Every plaque and adipose tissue sample contained linolelaidic acid (C18:2 trans-9 trans-12) which is derived exclusively from linoleic acid, as well as conjugated dienes of linoleic acid (CLA) produced during oxidative processes. The presence of trans isomers of fatty acids in the atheromatous plaque seems to be of relevance to plaque formation. Of much concern is the detection of elaidic and linolelaidic acids which adversely affect the physiologically important metabolism of eicosanoids. The TFA pool in adipose tissue has little effect on the amount of these acids in the atheromatous plaque. Apparently, the presence of TFA in atheromatous plaques is the result of processes taking place during plaque formation and maturation.
Ewa Stachowska; Barbara Dołegowska; Dariusz Chlubek; Teresa Wesołowska; Kazimierz Ciechanowski; Piotr Gutowski; Halina Szumiłowicz; Radosław Turowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-27
Journal Detail:
Title:  European journal of nutrition     Volume:  43     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-13     Completed Date:  2005-02-03     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  313-8     Citation Subset:  IM    
Dept. of Biochemistry & Chemistry, Pomeranian Medical University, al. Powstancow Wlkp 72, 70-111 Szczecin, Poland.
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MeSH Terms
Adipose Tissue / metabolism*
Aorta, Abdominal / pathology
Arteriosclerosis / metabolism*,  pathology
Chromatography, Gas
Dietary Fats / administration & dosage*,  metabolism*
Femoral Artery / pathology
Iliac Artery / pathology
Middle Aged
Trans Fatty Acids / administration & dosage*,  chemistry,  metabolism*
Reg. No./Substance:
0/Dietary Fats; 0/Trans Fatty Acids

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