| Dietary trans fatty acids alter diaphragm phospholipid fatty acid composition, triacylglycerol content and glucose transport in rats. | |
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MedLine Citation:
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PMID: 16079026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study evaluates the effect of dietary trans fatty acids on diaphragm phospholipid fatty acid composition, intramyocellular triacylglycerol content and insulin-stimulated glucose uptake in comparison with dietary saturated fatty acids. Male weanling WNIN rats were divided into three groups and fed for 3 months on one of the following diets containing 10 % oil differing in fatty acid composition: control diet, saturated fatty acid diet and trans fatty acid diet. Dietary trans fatty acids increased the intramyocellular triacylglycerols and decreased the ratio of 20 : 4n-6 to 18 : 2n-6 and long-chain PUFA levels (20 %) in diaphragm phospholipids, indicating inhibition of PUFA biosynthesis. However, saturated fatty acids decreased both 18 : 2n-6 and 20 : 4n-6 without change in the ratio. Trans fatty acid-induced alterations in diaphragm phospholipid fatty acid composition and intramyocellular triacylglycerol content were associated with decreased insulin-stimulated glucose transport in the diaphragm. These observations suggest that dietary trans fatty acids decrease diaphragm insulin sensitivity, possibly due to increased intramyocellular triacylglycerol accumulation and decreased long-chain PUFA in phospholipids. |
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Authors:
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Saravanan Natarajan; Ahamed Ibrahim; |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 93 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-08-04 Completed Date: 2005-09-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 829-33 Citation Subset: IM |
Affiliation:
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National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania P.O, Hyderabad 500 007, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diaphragm / metabolism* Diet Dietary Fats / administration & dosage, pharmacology* Fatty Acids / metabolism* Fatty Acids, Unsaturated / metabolism Glucose / metabolism* Male Phospholipids / metabolism* Rats Trans Fatty Acids / administration & dosage, pharmacology* Triglycerides / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids; 0/Trans Fatty Acids; 0/Triglycerides; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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