Document Detail

Dietary supplementation with n-3 polyunsaturated fatty acids in early childhood: effects on blood pressure and arterial structure and function at age 8 y.
MedLine Citation:
PMID:  19515739     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: n-3 Fatty acid supplementation in adults results in cardiovascular benefits. However, the cardiovascular effects of n-3 supplementation in early childhood are unknown. OBJECTIVE: The objective was to evaluate blood pressure (BP) and arterial structure and function in 8-y-old children who had participated in a randomized controlled trial of dietary n-3 and n-6 modification over the first 5 y of life. DESIGN: The children (n = 616; 49% girls) were randomly assigned antenatally to active (n = 312; increase in n-3 intake and decrease in n-6 intake) or control (n = 304) diet interventions implemented from the time of weaning or introduction of solids until 5 y of age. At age 8.0 +/- 0.1 y, BP, carotid intima-media thickness, carotid artery distensibility, augmentation index, and brachial pulse wave velocity were measured in 405 of these children. Venous blood was collected for measurement of plasma fatty acids, lipoproteins, high-sensitivity C-reactive protein, and asymmetric dimethylarginine. Plasma fatty acid concentrations were also assessed during the intervention. RESULTS: Plasma concentrations of n-3 fatty acids were higher and of n-6 were lower in the active than in the control diet group at 18 mo and 3 and 5 y (P < 0.0001). Concentrations of n-3 and n-6 fatty acids were similar at 8 y. At 8 y of age, no significant differences were found in BP, carotid intima-media thickness, carotid artery distensibility, augmentation index, asymmetric dimethylarginine, high-sensitivity C-reactive protein, or lipoproteins between diet groups. CONCLUSION: A dietary supplement intervention to increase n-3 and decrease n-6 intakes from infancy until 5 y does not result in significant improvements in arterial structure and function at age 8 y. This trial was registered at the Australian Clinical Trials Registry as ACTRN012605000042640.
Julian G Ayer; Jason A Harmer; Wei Xuan; Brett Toelle; Karen Webb; Catarina Almqvist; Guy B Marks; David S Celermajer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-06-10
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-08-03     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  438-46     Citation Subset:  AIM; IM    
Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Sydney, Australia.
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MeSH Terms
Blood Flow Velocity / drug effects
Blood Pressure / drug effects*
Brachial Artery / drug effects,  physiology
C-Reactive Protein / metabolism
Carotid Arteries / drug effects,  physiology
Child Nutritional Physiological Phenomena / physiology*
Child, Preschool
Compliance / drug effects
Dietary Supplements
Fatty Acids, Omega-3 / administration & dosage*,  blood,  pharmacology
Fatty Acids, Unsaturated / administration & dosage,  blood,  pharmacology
Tunica Intima / pathology
Vascular Resistance*
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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