| Dietary supplementation with hydroxypropyl-distarch phosphate from waxy maize starch increases resting energy expenditure by lowering the postprandial glucose-dependent insulinotropic polypeptide response in human subjects. | |
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MedLine Citation:
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PMID: 21338535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to investigate the effects of hydroxypropyl-distarch phosphate (HDP) supplementation on postprandial energy metabolism and glucose-dependent insulinotropic polypeptide (GIP) in human subjects. A total of ten healthy male subjects, with a mean BMI of 23·6 (SEM 1·3) kg/m(2), age 35·2 (SEM 1·9) years and body weight 71·1 (SEM 4·0) kg, participated in a randomised, cross-over, intervention study with two different test meals (1673·6 kJ) containing either waxy maize starch or HDP from waxy maize starch (degree of substitution 0·154, P content 0·004 %). Resting energy expenditure (REE) and blood concentrations of various biomarkers were measured at fasting and up to 180 min postprandially. Indirect calorimetry showed that the HDP meal caused higher REE (P < 0·05) and fat utilisation (P < 0·001) than the waxy maize starch meal. The HDP meal led to significantly lower postprandial glucose (P < 0·05), insulin (P < 0·05) and GIP (P < 0·05) responses than the waxy maize starch meal. Both postprandial REE (R - 0·576, P < 0·01) and fat utilisation (R - 0·514, P < 0·05) were negatively correlated with the postprandial GIP response, but not with the glucose and insulin responses. In conclusion, dietary supplementation with HDP lowers postprandial GIP and increases postprandial REE and fat utilisation in healthy humans. An HDP-rich diet may therefore have beneficial implications in weight management. Further studies are required to confirm the efficacy in overweight or obese subjects, and to determine the precise mechanisms. |
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Authors:
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Akira Shimotoyodome; Junko Suzuki; Yoji Kameo; Tadashi Hase |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-02-22 |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-17 Completed Date: 2011-08-25 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 96-104 Citation Subset: IM |
Affiliation:
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Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan. shimotoyodome.akira@kao.co.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calorimetry, Indirect Cross-Over Studies Dietary Fats / metabolism Dietary Supplements Energy Metabolism / drug effects* Gastric Inhibitory Polypeptide / metabolism* Hetastarch / analogs & derivatives*, chemistry, pharmacology Humans Male Postprandial Period Starch / chemistry* Zea mays / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 53124-00-8/hydroxypropyl distarch phosphate; 59392-49-3/Gastric Inhibitory Polypeptide; 9005-25-8/Starch; 9005-27-0/Hetastarch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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