Document Detail


Dietary supplementation with L-arginine or placebo in women with pre-eclampsia.
MedLine Citation:
PMID:  14678093     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: To investigate the effect of dietary intake of the NO-donor L-arginine on the diastolic blood pressure in women with pre-eclampsia. METHODS: A randomized double-blind study was designed to compare the effect of L-arginine and placebo in pre-eclamptic women with gestational length ranging from 28+0 to 36+0 weeks. The women received orally 12 g of L-arginine or placebo daily for up to 5 days. The primary end-point was to identify a difference in diastolic blood pressure alteration between the two groups after 2 days of intervention. Secondary end-points included the interval from study start to delivery, the proportion of women delivered after 2, 5 or 10 days from treatment start and mean birth weight. RESULTS: There was no statistically significant alteration in diastolic blood pressure in the L-arginine group compared with the placebo group after 2 days of treatment (p = 0.4). No differences in the proportions of women delivered by day 2, 5 or 10 after study start, in the mean interval from study start to delivery, or in mean birth weight percentile were observed between the two groups. CONCLUSIONS: Oral L-arginine supplementation did not reduce mean diastolic blood pressure after 2 days of treatment compared with placebo in pre-eclamptic patients with gestational length varying from 28 to 36 weeks. Whether L-arginine treatment could be clinically beneficial for the mother or the fetus if started earlier in the disease process than for the women in our study remains to be seen.
Authors:
Anne Cathrine Staff; Lillian Berge; Guttorm Haugen; Bjorg Lorentzen; Bente Mikkelsen; Tore Henriksen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-17     Completed Date:  2004-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Affiliation:
Departments of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien 166, 0450 Oslo, Norway. annetine.staff@ulleval.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Arginine / administration & dosage*
Blood Pressure
Dietary Supplements*
Double-Blind Method
Female
Gestational Age
Humans
Pre-Eclampsia / drug therapy*
Pregnancy
Treatment Outcome
Chemical
Reg. No./Substance:
74-79-3/Arginine
Comments/Corrections
Comment In:
Acta Obstet Gynecol Scand. 2004 Sep;83(9):871; author reply 872   [PMID:  15315604 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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