| Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. | |
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MedLine Citation:
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PMID: 14678093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To investigate the effect of dietary intake of the NO-donor L-arginine on the diastolic blood pressure in women with pre-eclampsia. METHODS: A randomized double-blind study was designed to compare the effect of L-arginine and placebo in pre-eclamptic women with gestational length ranging from 28+0 to 36+0 weeks. The women received orally 12 g of L-arginine or placebo daily for up to 5 days. The primary end-point was to identify a difference in diastolic blood pressure alteration between the two groups after 2 days of intervention. Secondary end-points included the interval from study start to delivery, the proportion of women delivered after 2, 5 or 10 days from treatment start and mean birth weight. RESULTS: There was no statistically significant alteration in diastolic blood pressure in the L-arginine group compared with the placebo group after 2 days of treatment (p = 0.4). No differences in the proportions of women delivered by day 2, 5 or 10 after study start, in the mean interval from study start to delivery, or in mean birth weight percentile were observed between the two groups. CONCLUSIONS: Oral L-arginine supplementation did not reduce mean diastolic blood pressure after 2 days of treatment compared with placebo in pre-eclamptic patients with gestational length varying from 28 to 36 weeks. Whether L-arginine treatment could be clinically beneficial for the mother or the fetus if started earlier in the disease process than for the women in our study remains to be seen. |
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Authors:
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Anne Cathrine Staff; Lillian Berge; Guttorm Haugen; Bjorg Lorentzen; Bente Mikkelsen; Tore Henriksen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 83 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-17 Completed Date: 2004-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 103-7 Citation Subset: IM |
Affiliation:
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Departments of Obstetrics and Gynecology, Ulleval University Hospital, Kirkeveien 166, 0450 Oslo, Norway. annetine.staff@ulleval.no |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arginine / administration & dosage* Blood Pressure Dietary Supplements* Double-Blind Method Female Gestational Age Humans Pre-Eclampsia / drug therapy* Pregnancy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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74-79-3/Arginine |
| Comments/Corrections | |
Comment In:
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Acta Obstet Gynecol Scand. 2004 Sep;83(9):871; author reply 872
[PMID:
15315604
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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