Document Detail

Dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants: effects on cerebral maturation.
MedLine Citation:
PMID:  12412870     Owner:  NLM     Status:  MEDLINE    
AIM: To study the influence of dietary-supplied long-chain polyunsaturated fatty acids on structural brain maturation in preterm infants and to investigate parameters of functional brain development, relating them to structural maturation. Other studies have suggested that dietary supplementation of long-chain polyunsaturated fatty acids in preterm infants may enhance their visual development. The influence on structural brain development has never been evaluated. METHODS: In a prospective, double-blind study, 42 formula-fed premature infants were randomized to be fed either a standard preterm formula without long-chain polyunsaturated fatty acids or an identical formula supplemented with docosahexaenoic acid (0.015 g/100 ml) and arachidonic acid (0.031 g/100 ml). Infants with significant cerebral damage, retinopathy, chronic disease or feeding problems were excluded. Follow-up was focused on assessment of cerebral myelination by MRI. Psychomotor, mental and visual development was analysed and flash-visual evoked potentials were recorded. RESULTS: It was found that progress of myelination, mental and motor development and latencies of visual evoked potentials were not positively influenced by supplementation of long-chain polyunsaturated fatty acids. At each test age, visual acuity was slightly better in the supplemented infants than in the non-supplemented infants, but the difference never reached significance level CONCLUSION: Supplementation of long-chain polyunsaturated fatty acids did not have a demonstrable positive influence on structural brain maturation. Related to this finding, in this small cohort of preterm infants without significant neurological damage, sample size being restricted by strict inclusion criteria and MRI procedures, no significant positive effects were found on psychomotor, mental and visual development.
G van Wezel-Meijler; M S van der Knaap; J Huisman; E J Jonkman; J Valk; H N Lafeber
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  91     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-02-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  942-50     Citation Subset:  IM    
Department of Paediatrics, Free University Medical Centre, Amsterdam, The Netherlands.
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MeSH Terms
Analysis of Variance
Arachidonic Acid / administration & dosage*
Brain / growth & development*,  pathology
Child Development / physiology*
Dietary Supplements*
Docosahexaenoic Acids / administration & dosage*
Double-Blind Method
Evoked Potentials, Visual
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Magnetic Resonance Imaging
Prospective Studies
Reference Values
Sensitivity and Specificity
Visual Acuity
Reg. No./Substance:
25167-62-8/Docosahexaenoic Acids; 506-32-1/Arachidonic Acid

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